59005-65-1Relevant academic research and scientific papers
Transition-metal free 2-arylbenzoxazole formation from aryl amides and cyclohexanones
Cao, Xiangxiang,Cheng, Xiufang,Bai, Yang,Liu, Saiwen,Deng, Guo-Jun
supporting information, p. 4644 - 4648 (2015/02/19)
A transition-metal-free method for the synthesis of 2-arylbenzoxazoles from readily available cyclohexanones and benzamides is described. The combined use of KI, p-TsOH and DMSO significantly improved the reaction yields. Non-aromatic cyclohexanones were smoothly dehydrogenated and acted as the aryl source using oxygen as the oxidant.
Synthesis of 2-arylbenzoxazoles by copper-catalyzed intramolecular oxidative C-O coupling of benzanilides
Ueda, Satoshi,Nagasawa, Hideko
supporting information; experimental part, p. 6411 - 6413 (2009/03/11)
(Chemical Equation Presented) No need for additives: A wide variety of functionalized 2-arylbenzoxazoles can be prepared with high functional-group tolerance and regioselectivity by a copper-catalyzed intramolecular oxidative C-O coupling of benzanilides. The catalytic cycle is completed by the regeneration of the copper catalyst using molecular oxygen as a terminal oxidant without the need for additives.
