59005-75-3Relevant academic research and scientific papers
Kinetic study of trifluoromethylation with S-(trifluoromethyl) dibenzothiophenium salts
Ono, Taizo,Umemoto, Teruo
, p. 163 - 166 (1996)
The kinetic parameters were determined for C-trifluoromethylation of aniline with S-(trifluoromethyl)dibenzothiophenium triflate (1), its 3,7-dinitro derivative (2) and S-(trifluoromethyl)diphenylsulfonium triflate (3) in DMF-d7. The higher reactivity of heterocyclic 1 compared with non-heterocyclic 3 could be explained on the basis of its greatly enhanced activation entropy (ΔS≠: -11.2 cal mol-1 K-1 for 1; -47.1 for 3), but not its enhanced activation enthalpy (ΔH≠: 21.2 kcal mol-1 for 1; 12.1 for 3). The aromatic delocalization of the heterocyclic ring may thus be only slightly disturbed by the S-trifluoromethyl substituent. The high reactivity of 2 was attributed to the great electron deficiency caused by two nitro groups in addition to the heterocyclic salt system (ΔH≠ 17.0 kcal mol-1, ΔS≠ -9.1 cal mol-1 K-1 for 2). The reaction mechanism is discussed; the conventional SN2 attack mechanism was ruled out and a mechanism for a side-on attack to the CF3-S bond may possibly be applicable.
