59013-75-1

Usage

Uses

Used in Pharmaceutical Industry:
L-Isovaline, 4-(methylthio)(9CI) is used as a building block in the synthesis of pharmaceutical compounds for various therapeutic applications. Its unique structure allows for the creation of novel drugs with potential benefits in treating different medical conditions.
Used in Material Science:
In the field of material science, L-Isovaline, 4-(methylthio)(9CI) is utilized as a component in the development of new materials and compounds. Its properties may contribute to the creation of innovative materials with specific characteristics, such as improved stability or reactivity.
Further research is necessary to fully understand the capabilities and potential applications of L-Isovaline, 4-(methylthio)(9CI) in various industries. As our understanding of L-Isovaline, 4-(methylthio)- (9CI) grows, it may find its way into new and exciting uses that are yet to be discovered.

Upstream product

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Relevant academic research and scientific papers

Synthesis of α-Methyl-homocysteinethiolactone

A facile high yield large scale methylation procedure affording 2c is reported utilizing the N-bis(methylthio)-methylen-protected derivative 4a as an intermediate.The optical resolution of racemic 2c is described leading to (S)-2b.In addition the thiolactone 2c undergoes oxidative ring opening by bromine to the corresponding sulphonic acid 5. - Keywords.Radioprotection; Homocysteine derivatives; α-Substituted α-amino acid.

Kinetic Resolution of Unnatural and Rarely Occuring Amino Acids: Enantioselective Hydrolysis of N-Acyl Amino Acids Catalyzed by Acylase I

Acylase I (aminoacylase; N-acylamino-acid amidohydrolase, EC 3.5.1.14, from porcine kidney and the fungus Aspergillus) is broadly applicable enzymatic catalyst for the kinetic resolution of unnatural and rarely occuring α-amino acids.Its enantioselectivity for the hydrolysis of N-acyl L-α-amino acids is nearly absolute, yet it accepts substrates having a wide range of structure and functionality.This paper reports the initial rates of enzyme-catalyzed hydrolysis of over 50 N-acyl amino acids and analogues, the stabilities of the enzymes in aqueous and aqueous/organic solutions, and the effects of different acyl groups and metal ions on the rates of enzymatic hydrolysis.Eleven α-amino and α-methyl α-amino acids were resolved on a 2-29-g scale.Crude L- and D-amino acid products had generally >90percent ee.The utility of resolved amino acids as chiral synthons was illustrated by the preparation of (R)- and (S)-1-butene oxide and the diastereoselective (cis:trans, 7-8:1) iodolactonization of three 2-amino-4-alkenoic acid derivatives.