59014-27-6

Usage

Uses

Used in Pharmaceutical Synthesis:
(8S,2R)-Diaminononanedioic acid is used as a building block for the synthesis of various pharmaceuticals and biologically active compounds. Its unique structure and functional groups make it a valuable component in the development of new drugs and therapeutic agents.
Used in Antimicrobial Agents Development:
(8S,2R)-Diaminononanedioic acid is used as an antimicrobial agent for its potential to exhibit antimicrobial and antibiofilm properties. It can be utilized in the development of new antimicrobial agents to combat resistant bacteria and improve public health.
Used in Biomedical Research:
(8S,2R)-Diaminononanedioic acid is used as a research tool in the study of bacterial cell wall structure and function. Its presence in the peptidoglycan cell walls of gram-negative bacteria makes it an important compound for understanding the mechanisms of bacterial growth, division, and pathogenesis.
Used in Chemical Synthesis Industry:
(8S,2R)-Diaminononanedioic acid is used as a key intermediate in the synthesis of various chemical compounds and materials. Its versatile structure and functional groups make it a valuable building block for the development of new chemical products and applications.

Upstream product

• 28817-54-1 1,7-bis-acetylamino-heptane-1,1,7,7-tetracarboxylic acid tetraethyl ester 
• 111-24-0 1,5-dibromo-pentane 

Relevant academic research and scientific papers

Synthetic Models of Quasi-Stable Amyloid β40 Oligomers with Significant Neurotoxicity

The formation of soluble oligomers of amyloid β42 and 40 (Aβ42, Aβ40) is the initial event in the pathogenesis of Alzheimer's disease (AD). Based on previous systematic proline replacement and solid-state NMR, we proposed a toxic dimer structure of Aβ42, a highly aggregative alloform, with a turn at positions 22 and 23, and a hydrophobic core in the C-terminal region. However, in addition to Aβ42, Aβ40 dimers can also contribute to AD progression because of the more abundance of Aβ40 monomer in biological fluids. Here, we describe the synthesis and characterization of three dimer models of the toxic-conformation constrained E22P-Aβ40 using l,l-2,6-diaminopimeric acid (DAP) or l,l-2,8-diaminoazelaic acid (DAZ) linker at position 30, which is incorporated into the intermolecular parallel β-sheet region, and DAP at position 38 in the C-terminal hydrophobic core. E22P-A30DAP-Aβ40 dimer (1) and E22P-A30DAZ-Aβ40 dimer (2) existed mainly in oligomeric states even after 2 weeks incubation without forming fibrils, unlike the corresponding monomer. Their neurotoxicity toward SH-SY5Y neuroblastoma cells was very weak. In contrast, E22P-G38DAP-Aβ40 dimer (3) formed β-sheet-rich oligomeric aggregates, and exhibited more potent neurotoxicity than the corresponding monomer. Ion mobility-mass spectrometry suggested that high molecular-weight oligomers (12-24-mer) of 3 form, but not for 1 and 2 after 4 h incubation. These findings indicate that formation of the hydrophobic core at the C-terminus, rather than intermolecular parallel β-sheet, triggers the formation of toxic Aβ oligomers. Compound 3 may be a suitable model for studying the etiology of Alzheimer's disease.

Double chain peptide compounds having hemoregulatory activity

Dipeptide compounds are disclosed, the two peptide chains being joined together at a Cα-atom of a non-terminal amino acid by a divalent bridging group --A--. The Cα-atoms joined to group --A-- are located in equivalent positions in each peptide and each lack their native α-side chain. The bridged dipeptide compounds disclosed have a stimulating activity on cell division, especially for myelopoietic and bone marrow cells.