59015-33-7Relevant academic research and scientific papers
Consecutive three-component synthesis of (hetero)arylated propargyl amides by chemoenzymatic aminolysis-Sonogashira coupling sequence
Hassan, Sidra,Ullrich, Anja,Müller, Thomas J. J.
, p. 1571 - 1576 (2015/01/30)
A novel chemoenzymatic three-component synthesis of (hetero)arylated propargyl amides in good yields based upon Novozyme 435 (Candida antarctica lipase B (CAL-B)) catalyzed aminolysis of methyl carboxylates followed by Sonogashira coupling with (hetero)aryliodides in a consecutive one-pot fashion has been presented. This efficient methodology can be readily concatenated with a CuAAC (Cu catalyzed alkyne azide cycloaddition) as a third consecutive step to furnish 1,4-disubstituted 1,2,3-triazole ligated arylated propargyl amides. This one-pot process can be regarded as a transition metal catalyzed sequence that takes advantage of the copper source still present from the cross-coupling step.
The Photo-Dehydro-Diels-Alder (PDDA) reaction - A powerful method for the preparation of biaryls
Wessig, Pablo,Mueller, Gunnar,Pick, Charlotte,Matthes, Annika
, p. 464 - 477 (2007/12/27)
The photochemically initiated dehydro-Diels-Alder (PDDA) reaction is an efficient and versatile method for the preparation of biaryls. The ring closure may take place both inter- and intramolecularly, of which the intramolecular variant is more productive
