59017-01-5

Upstream product

• 1202014-20-7 Boc-Phe-Sar-O^tBu 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 478659-08-4 (+)-methyl N'-(t-butyloxycarbonyl)-L-phenylalanyl-N-methylglycinate 

Downstream Products

• 478659-17-5 (+)-(3S)-3-benzyl-5-ethoxy-1-methyl-3,6-dihydro-1H-2-pyrazinone 
• 478659-51-7 (+)-(1R,4S)-4-benzyl-1-hydroxy-2-methyl-1-phenyl-2,4-dihydro-(1H)-pyrazino[2,1-b]quinazoline-3,6-dione 
• 478659-40-4 (+)-(4S)-4-benzyl-2-methyl-1-methylene-2,4-dihydro-1H-pyrazino[2,1-b]quinazoline-3,6-dione 
• 478659-48-2 (+)-(4S)-4-benzyl-2-methyl-2,4-dihydropyrazino[2,1-b]quinazoline-1,3,6-trione 
• 478659-23-3 (+)-(4S)-4-benzyl-2-methyl-2,4-dihydro-1H-pyrazino[2,1-b]quinazoline-3,6-dione 

Relevant academic research and scientific papers

Synthesis and in vitro bone cell activity of analogues of the cyclohexapeptide dianthin G

The cyclohexapeptide natural product dianthin G promotes osteoblast (bone-forming cell) proliferation in vitro at nanomolar concentrations, and is therefore considered a promising candidate for the treatment of osteoporosis. An Nα-methyl amide bond scan of dianthin G was performed to probe the effect of modifying amide bonds on osteoblast proliferation. In addition, to provide greater structural diversity, a series of dicarba dianthin G analogues was synthesised using ring closing metathesis. Dianthin G and one novel dicarba analogue increased the number of human osteoblasts and importantly they did not increase osteoclast (bone-resorbing cell) differentiation in bone marrow cells.

Linear and cyclic dipeptides with antimalarial activity

Several natural and synthetic polypeptides possess important antimalarial activity. Shorter peptides with potent antimalarial activity have also been described, among them linear di-, tri-, tetra- and pentapeptides and their cyclic analogs. In an attempt

Efficient microwave assisted syntheses of 2,5-diketopiperazines in aqueous media

Aqueous in situ one-pot N-Boc-deprotection-cyclization of Nα-Boc-dipeptidyltert-butyl and methyl esters under microwave irradiation afforded 2,5-diketopiperazines (DKPs) in excellent yields. This protocol is rapid, safe, environmentally friendly, and high

Acid-promoted reactions in 1-hydroxy, 1-dimethylaminomethyl and 1-methylene-4-arylmethyl-2,4-dihydro-1H-pyrazino[2,1-b]quinazoline-3,6-diones

The 1-dimethylaminomethyl or 1-methylene group of the title compounds was introduced through a Mannich or a tandem of Mannich-Hofmann reactions as the final step of a protocol that is shorter than other previously described for these precursors of N-acyliminium species. In these compounds, the acid-promoted intramolecular cyclizations of Pictet-Spengler-type were restricted to the N(2)-unsubstituted compounds, while their N(2)-methyl substituted analogues gave instead dimerization products. The cyclization was effective with 1-hydroxy-1,2-disubstituted compounds, which were obtained through addition of a Grignard reagent to 2H,4H-pyrazino[2,1-b]quinazoline-1,3,6-triones.