59018-47-2

Usage

Uses

Used in Pharmaceutical Industry:
2-AMINO-3,5-DIBROMOBENZENESULFONAMIDE is used as an intermediate in the synthesis of various pharmaceuticals for its potential biological activity. Its presence in the molecular structure can contribute to the development of new drugs with enhanced properties, such as improved efficacy and targeted action against specific diseases.
Used in Agrochemical Industry:
In the agrochemical sector, 2-AMINO-3,5-DIBROMOBENZENESULFONAMIDE is utilized as a precursor in the production of agrochemicals. Its antibacterial properties can be harnessed to create compounds that protect crops from bacterial infections, thereby increasing agricultural productivity and crop yields.
Used in Organic Synthesis:
2-AMINO-3,5-DIBROMOBENZENESULFONAMIDE serves as a building block in organic synthesis, allowing chemists to create new organic compounds with a range of properties. Its unique structure, including the bromine atoms and the sulfonamide group, provides a foundation for the development of novel materials with applications in various fields, such as materials science, chemical engineering, and environmental chemistry.

Upstream product

• 3306-62-5 2-AMINOBENZENESULFONAMIDE 

Downstream Products

• 53661-61-3 3-benzyl-5,7-dibromo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide 
• 53661-60-2 5,7-dibromo-3-phenyl-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide 
• 101064-04-4 4-(5,7-Dibromo-1,1-dioxo-1,4-dihydro-1λ⁶-benzo[1,2,4]thiadiazin-3-yl)-butyric acid 
• 101063-95-0 3-(5,7-Dibromo-1,1-dioxo-1,4-dihydro-1λ⁶-benzo[1,2,4]thiadiazin-3-yl)-propionic acid 

Relevant academic research and scientific papers

A scaffold replacement approach towards new sirtuin 2 inhibitors

Sirtuins (SIRT1–SIRT7) are an evolutionary conserved family of NAD+-dependent protein deacylases regulating the acylation state of ε-N-lysine residues of proteins thereby controlling key biological processes. Numerous studies have found association of the aberrant enzymatic activity of SIRTs with various diseases like diabetes, cancer and neurodegenerative disorders. Previously, we have shown that substituted 2-alkyl-chroman-4-one/chromone derivatives can serve as selective inhibitors of SIRT2 possessing an antiproliferative effect in two human cancer cell lines. In this study, we have explored the bioisosteric replacement of the chroman-4-one/chromone core structure with different less lipophilic bicyclic scaffolds to overcome problems associated to poor physiochemical properties due to a highly lipophilic substitution pattern required for achieve a good inhibitory effect. Various new derivatives based on the quinolin-4(1H)-one scaffold, bicyclic secondary sulfonamides or saccharins were synthesized and evaluated for their SIRT inhibitory effect. Among the evaluated scaffolds, the benzothiadiazine-1,1-dioxide-based compounds showed the highest SIRT2 inhibitory activity. Molecular modeling studies gave insight into the binding mode of the new scaffold-replacement analogues.

Iodine-mediated synthesis of 3-acylbenzothiadiazine 1,1-dioxides

An iodine-mediated synthesis of 3-acylbenzothiadizine 1,1-dioxides is described. A range of electronically diverse acetophenones reacted well with several 2-aminobenzenesulfonamides, affording 3-acylbenzothiadiazine 1,1-dioxides in good yields.

Novel compounds and their use as positive AMPA receptor modulators

The invention provides novel compounds represented by the general formula 5 compound represented by the formula: wherein the bond represented by the broken line may be a single, a double bond or absent; and if the bond is absent, then the nitrogen is substituted with a hydrogen and R2; X represents SO2 or C═O or CH2; Y represents —CH(R4)—, —N(R4)— or —N(R4)—CH2—, O; and the meaning of R2, R3, R4, R5, R6, R7, and R8 are as defined in the application The compounds are useful as positive modulators of the AMPA-receptor.