59023-30-2Relevant academic research and scientific papers
Reactions of 1,2-Dimethylimidazole, Particularly its Metallation
Iddon, Brian,Lim, Bee Lan
, p. 271 - 277 (2007/10/02)
A re-examination of the metallation of 1,2-dimethylimidazole has shown that, after quenching of reaction mixtures with suitable reagents, single products may arise from substitution either in the 2-methyl group or in the 5-position or mixtures of both products may arise, depending on the metallating reagent, solvent, and reaction conditions. 1,2-Dimethylimidazol-5-yl-lithium was prepared by reaction of 1,2-dimethyl-5-trimethylstannylimidazole (13) with n-butyl-lithium in tetrahydrofuran at -100 deg C.The corresponding 5-trimethylsilyl compounds (12) was metallated by n-butyl-lithium exclusively in the 2-methyl group. 1,2-Dimethylimidazol-5-yl-lithium was shown to undergo transmetallation reactions at temperatures higher than -100 deg C.An improved procedure is given for the synthesis of 1,2-dimethylimidazole-5-carbaldehyde via hydroxymethylation of 1,2-dimethylimidazole and oxidation of the 5-hydroxymethyl group with nitric acid.
Photoaddition of Ketones to Imidazoles, Thiazoles, Isothiazoles and Isoxazoles. Synthesis of their Oxetanes
Nakano, Tatsuhiko,Rodriguez, Wilma,de Roche, Severina Z.,Larrauri, Jose M.,Rivas, Carlos,Perez, Carmen
, p. 1777 - 1780 (2007/10/02)
Imidazole itself did not undergo photoaddition reactions with ketones.However, irradiation of 1-acetyl and 1-benzoylimidazole, and 1,1-carbonyldiimidzole with benzophenone yielded oxetanes.On irradiation with carbonyl compounds, 1,2-dimethylimidazole and
