590366-82-8

Upstream product

• 173388-39-1 (1R,4E,3aR,7aR)-4-bromomethylene-7a-methyl-1-[(1S)-methyl-2-p-toluenesulfonyloxyethyl]perhydroindene 
• 342645-83-4 (S)-2-[(1R,3aR,7aR)-octahydro-7a-methyl-4-oxo-4H-inden-1-yl]propyl 4-methylbenzenesulfonate 
• 173388-40-4 (R)-3-{(1R,3aR,7aR)-4-[1-Bromo-meth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-butyronitrile 
• 173388-41-5 (1R,4E,3aR,7aR)-4-bromomethylene-1-[(1R)-2-formyl-1-methylethyl]-7a-methylperhydroindene 
• 203126-90-3 (3S,4S,5R)-3,5-bis[(tert-butyldimethylsilyl)oxy]-4-methyloct-1-en-7-yne 
• 173388-43-7 (S)-5-{(R)-2-[(1R,4E,3aR,7aR)-4-bromomethylene-7a-methylperhydroinden-1-yl]propyl}-3-methylenedihydrofuran-2-one 

Relevant academic research and scientific papers

VITAMIN D3 DERIVATIVES AND REMEDIES USING THE SAME

A vitamin D3 derivative expressed by the following general formula (1) [wherein, R is a hydrogen atom or a methyl group, and A is a single bond, -CH2-, -CH=CH-, -CH2-CH=CH-, -CH=CH-CH=CH-, -C=C- or -CH2-C≡C-; an

Remarkable effect of 2[small alpha]-modification on the VDR antagonistic activity of 1small alpha-hydroxyvitamin D3-26,23-lactones.

Novel 2[small alpha]-methyl-, 2[small alpha]-(3-hydroxypropyl)- and 2[small alpha]-(3-hydroxypropoxy)-substituted 25-dehydro-1[small alpha]-hydroxyvitamin D-26,23-lactone derivatives were efficiently synthesized Reformatsky type allylation and palladium-c