590371-71-4

Basic information

• Product Name: 3-IODO-2-(TRIFLUOROMETHYL)PYRIDINE
• Synonyms: 3-IODO-2-(TRIFLUOROMETHYL)PYRIDINE;3-Iodo-alpha,alpha,alpha-trifluoro-2-picoline
• CAS NO: 590371-71-4
• Molecular Formula: C₆H₃F₃IN
• Molecular Weight: 272.99
• Product Categories: Pyridine series;Halides;Pyridines;Fluorine series
• Mol File: 590371-71-4.mol

Chemical Properties

• Melting Point: 42-43 °C(Solv: hexane (110-54-3))
• Boiling Point: 210.089 °C at 760 mmHg
• Flash Point: 80.859 °C
• Appearance: /
• Density: 1.975 g/cm³
• Vapor Pressure: 0.284mmHg at 25°C
• Refractive Index: 1.523
• Storage Temp.: 2-8°C
• PKA: -1.47±0.22(Predicted)
• CAS DataBase Reference: 3-IODO-2-(TRIFLUOROMETHYL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-IODO-2-(TRIFLUOROMETHYL)PYRIDINE(590371-71-4)
• EPA Substance Registry System: 3-IODO-2-(TRIFLUOROMETHYL)PYRIDINE(590371-71-4)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 590371-71-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-IODO-2-(TRIFLUOROMETHYL)PYRIDINE is used as an intermediate in the synthesis of pharmaceuticals for its ability to enhance the properties of target compounds. Its electron-withdrawing nature and the reactivity of the iodo substituent make it a valuable component in the development of new drugs with improved efficacy and selectivity.
Used in Agrochemical Industry:
3-IODO-2-(TRIFLUOROMETHYL)PYRIDINE is utilized as a building block in the creation of agrochemicals, where its strong electron-withdrawing properties can contribute to the effectiveness of pesticides and other agricultural chemicals. 3-IODO-2-(TRIFLUOROMETHYL)PYRIDINE aids in the design of molecules with increased stability and bioactivity, which is crucial for the development of more efficient and environmentally friendly agrochemicals.
Used in Organic Synthesis:
3-IODO-2-(TRIFLUOROMETHYL)PYRIDINE is employed as a versatile building block in organic synthesis, where its unique structural features allow for the preparation of a wide range of organic compounds. 3-IODO-2-(TRIFLUOROMETHYL)PYRIDINE's reactivity and electron-withdrawing properties make it suitable for various synthetic routes, leading to the creation of novel molecules with potential applications in different fields.

InChI:InChI=1/C6H3F3IN/c7-6(8,9)5-4(10)2-1-3-11-5/h1-3H

Upstream product

• 368-48-9 2-(trifluoromethyl)pyridine 

Downstream Products

• 131747-41-6 2-(trifluoromethyl)-4-pyridinecarboxylic acid 
• 590371-73-6 2-(trifluoromethyl)pyridine-4-iodide 

Relevant articles and documents

HETEROBICYCLIC METALLOPROTEASE INHIBITORS

The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of heterobicyclic MMP- 13 inhibiting compounds, that exhibit an increased potency in relation to currently known MMP- 13 inhibitors.

Recommendable routes to trifluoromethyl-substituted pyridine- and quinolinecarboxylic acids

As part of a case study, rational strategies for the preparation of all ten 2-, 3-, or 4-pyridinecarboxylic acids and all nine 2-, 3-, 4-, or 8-quinolinecarboxylic acids bearing trifluoromethyl substituents at the 2-, 3-, or 4-position were elaborated. The trifluoromethyl group, if not already present in the precursor, was introduced either by the deoxygenative fluorination of suitable carboxylic acids with sulfur tetrafluoride or by the displacement of ring-bound bromine or iodine by trifluoromethylcopper generated in situ. The carboxy function was produced by treatment of organolithium or organomagnesium intermediates, products of halogen/metal or hydrogen/ metal permutation, with carbon dioxide. ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).