590409-48-6Relevant academic research and scientific papers
Synthesis of oligonucleotides containing 2′-deoxyguanosine adducts of nitropyrenes
Colis, Laureen C.,Chakraborti, Debasis,Hilario, Pablo,McCarty, Christopher,Basu, Ashis K.
experimental part, p. 67 - 77 (2009/05/30)
Two different approaches to synthesize oligonucleotides containing the 2′-deoxyguanosine adducts formed by nitropyrenes are described. A direct reaction of an unmodified oligonucleotide with an activated nitropyrene derivative is a convenient biomimetic approach for generating the major adducts in DNA. A total synthetic approach, by contrast, involves several synthetic steps, including Buchwald-Hartwig Pd-catalyzed coupling, but can be used for incorporating both the major and minor adducts in DNA in high yield. Copyright Taylor & Francis Group, LLC.
Synthesis of N2 2'-deoxyguanosine adducts formed by 1-nitropyrene.
Chakraborti, Debasis,Colis, Laureen,Schneider, Renee,Basu, Ashis K
, p. 2861 - 2864 (2007/10/03)
[reaction: see text] Synthesis of N(2) 2'-deoxyguanosine adducts formed by the ubiquitous carcinogen, 1-nitropyrene, is reported. Various conditions of Buchwald-Hartwig palladium-catalyzed amination are examined. The most convenient synthetic approach inv
