590410-53-0Relevant articles and documents
Synthesis of substituted 3-phenyl-6H-pyrazolo[4,3-d]isoxazoles from corresponding 4-benzoyl-5-hydroxypyrazoles
Holzer, Wolfgang,Hahn, Katharina
, p. 303 - 308 (2003)
Treatment of 1,(3)-(di)substituted 4-benzoyl-5-hydroxypyrazoles with phosphorus oxychloride affords the corresponding 4-benzoyl-5-chloropyrazoles. Reaction of the latter with hydroxylamine leads to oximes, which can be cyclized to novel 3-phenyl-6H-pyrazolo[4,3-d]isoxazoles by treatment with sodium hydride in dimethyl formamide. Detailed nmr spectroscopic studies (1H, 13C) with all obtained compounds are presented.