590419-53-7Relevant academic research and scientific papers
Organocatalytic direct asymmetric aldol reactions in water
Mase, Nobuyuki,Nakai, Yusuke,Ohara, Naoko,Yoda, Hidemi,Takabe, Kunihiko,Tanaka, Fujie,Barbas III, Carlos F.
, p. 734 - 735 (2006)
We have developed direct asymmetric cross-aldol reactions that can be performed in water without addition of organic solvents. A bifunctional catalyst with a long hydrophobic alkyl chain efficiently catalyzed the reactions and afforded the desired aldol p
Highly enantioselective aldol reactions catalyzed by reusable upper rim-functionalized calix[4]arene-based L-proline organocatalyst in aqueous conditions
Li, Zheng-Yi,Chen, Yuan,Zheng, Chong-Qian,Yin, Yue,Wang, Liang,Sun, Xiao-Qiang
, p. 78 - 85 (2016/12/09)
A series of upper rim-functionalized calix[4]arene-based L-Proline derivatives have been synthesized and employed for the enantioselective aldol reactions between cyclic ketones and aromatic aldehydes in the presence of water. Good to excellent yields (up
Asymmetric direct aldol reaction of cyclohexanone catalyzed by (N′-benzyl-N′-D-prolyl)-trans-4-hydroxy-L-proline hydrazide
Cheng, Chuanling,Wang, Wenliang
scheme or table, p. 196 - 198 (2012/03/27)
A new proline catalyst, namely (N′-benzyl-N′-D-prolyl)-trans-4- hydroxy-L-proline hydrazide, has been prepared and proved to be a superior catalyst for the asymmetric aldol reaction of cyclohexanone and aromatic aldehydes, affording up to 98:2 dr and 98%
Highly enantioselective direct aldol reactions catalyzed by proline derivatives based on a calix[4]arene scaffold in the presence of water
Li, Zheng-Yi,Chen, Jia-Wen,Wang, Leyong,Pan, Yi
supporting information; experimental part, p. 2356 - 2360 (2009/12/08)
A series of proline-derived organocatalysts based on a calix[4]arene scaffold have been developed to catalyze direct aldol reactions in the presence of water. Under the optimal conditions, high yields (up to>99%), good enantioselectivities (up to >99% ee)
