590424-05-8

Basic information

• Product Name: N-[2-(DiethylaMino)ethyl]-2,4-diMethyl-1H-pyrrole-3-CarboxaMide
• Synonyms: N-[2-(DiethylaMino)ethyl]-2,4-diMethyl-1H-pyrrole-3-CarboxaMide
• CAS NO: 590424-05-8
• Molecular Formula: C₁₃H₂₃N₃O
• Molecular Weight: 237.34122
• Mol File: 590424-05-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 372.5°C at 760 mmHg
• Flash Point: 179.1°C
• Appearance: /
• Density: 1.029g/cm³
• Vapor Pressure: 9.6E-06mmHg at 25°C
• Refractive Index: 1.526
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 15.43±0.46(Predicted)
• CAS DataBase Reference: N-[2-(DiethylaMino)ethyl]-2,4-diMethyl-1H-pyrrole-3-CarboxaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-(DiethylaMino)ethyl]-2,4-diMethyl-1H-pyrrole-3-CarboxaMide(590424-05-8)
• EPA Substance Registry System: N-[2-(DiethylaMino)ethyl]-2,4-diMethyl-1H-pyrrole-3-CarboxaMide(590424-05-8)

Safety Data

• Hazardous Substances Data: 590424-05-8(Hazardous Substances Data)

Usage

General Description

N-[2-(Diethylamino)ethyl]-2,4-dimethyl-1H-pyrrole-3-Carboxamide is a chemical compound with the molecular formula C15H24N4O. It is a pyrrole derivative and is often used in pharmacological research as a potential drug candidate. N-[2-(Diethylamino)ethyl]-2,4-dimethyl-1H-pyrrole-3-Carboxamide has been studied for its potential therapeutic properties, including its potential use as an anti-cancer agent and for its effects on the central nervous system. Its structure includes a pyrrole ring with a carboxamide group and diethylaminoethyl substituents, which contribute to its pharmacological activity. The compound is found in various research literature and may have potential applications in the development of new medications.

InChI:InChI=1/C13H23N3O/c1-5-16(6-2)8-7-14-13(17)12-10(3)9-15-11(12)4/h9,15H,5-8H2,1-4H3,(H,14,17)

Upstream product

• 100-36-7 N,N-diethylethylenediamine 
• 17106-13-7 2,4-dimethyl-1H-pyrrole-3-carboxylic acid 
• 682341-85-1 3-(1H-Imidazol-1-ylcarbonyl)-2,4-dimethyl-1H-pyrrole 
• 590424-04-7 tert-butyl 4-[[[2-(diethylamino)ethyl]amino]carbonyl]-3,5-dimethyl-1H-pyrrole-2-carboxylate 
• 590424-03-6 N-[2-(diethylamino)ethyl]-3-oxobutanamide 

Downstream Products

• 557795-19-4 sunitinib 
• 342641-94-5 sunitinib 
• 356068-86-5 N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide 
• 341031-54-7 sunitinib malate 

Relevant articles and documents

High-purity L-sunitinib malate preparation method

The present invention discloses a high-purity L-sunitinib malate preparation method, which comprises the following reaction route defined in the specification, wherein the step a comprises that a B5 compound and 5-fluoroindol-2-one are subjected to an Aldol condensation reaction to obtain a sunitinib free base (B6 compound), the step b comprises that the B6 compound and L-malic acid are subjected to a salt forming reaction to obtain the L-sunitinib malate, and the step a and the step b are performed in a dark place. According to the present invention, the HPLC purity of the prepared L-sunitinib malate can achieve more than 99.8%, the single impurity content can be controlled at less than 0.1%, and the quality difficulty of the application of the L-sunitinib malate in the preparation is effectively solved.

Method of synthesizing indolinone compounds

Disclosed are methods of preparing pyrrole compounds of formula 14 and indolinone compounds of formula 1 via a synthetic route wherein the amide sidechain on the pyrrole moiety is attached prior to pyrrole formation. The compounds 14 produced by the methods herein are useful in the synthesis of compounds of formula 1, which are useful in the treatment of abnormal cell growth, such as cancer.

Method for catalyzing amidation reactions

The invention provides a method of preparing a compound of formula 2 wherein R1 and R6 are as defined herein, by a catalytic amidation process in the presence of added carbon dioxide. The inventive methods show surprising rate enhancement relative to the corresponding uncatalyzed reaction.