59049-59-1

Basic information

• Product Name: N-(2-Benzoyl-4-nitrophenyl)-2-[(2-cyanopropyl)methylamino]-N-methylacetamide
• Synonyms: C-720045;N-(2-Benzoyl-4-nitrophenyl)-2-[(2-cyanopropyl)methylamino]-N-methylacetamide
• CAS NO: 59049-59-1
• Molecular Formula: C21H22 N4 O4
• Molecular Weight: 394.42
• Mol File: 59049-59-1.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(2-Benzoyl-4-nitrophenyl)-2-[(2-cyanopropyl)methylamino]-N-methylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-Benzoyl-4-nitrophenyl)-2-[(2-cyanopropyl)methylamino]-N-methylacetamide(59049-59-1)
• EPA Substance Registry System: N-(2-Benzoyl-4-nitrophenyl)-2-[(2-cyanopropyl)methylamino]-N-methylacetamide(59049-59-1)

Safety Data

• Hazardous Substances Data: 59049-59-1(Hazardous Substances Data)

Upstream product

• 50840-30-7 (R)-2-Methyl-3-methylamino-propionitrile 
• 50840-35-2 5-Nitro-2-methylchloracetamidobenzophenon 

Relevant articles and documents

Cyanoalkylamino-amido benzophenones

The present invention relates to pharmacologically valuable new benzophenone derivatives having a pronounced sedative action on the central nervous system and some of which also possess muscle-relaxing and aggression-inhibiting properties. These new derivatives have the structural formula SPC1 And their addition salts, in which R1 and R2 are substituents selected from the group consisting of hydrogen, alkyl having 1-5 carbon atoms, alkenyl having 2 to 4 carbon atoms, alkinyl having 2 to 4 carbon atoms or β-bromoallyl (--CH2 --CBr = CH2) ; R3 is --CN; n is an integer selected from 1 and 2; and m is an integer selected from 1, 2 and 3, wherein the rings A and B may be substituted, ring A being substituted preferably with a halogen such as chlorine or with nitro, trifluoromethyl, methyl, methoxy or methylmercapto, preferably in the 5 position, and ring B being preferably substituted in the 2' position with chlorine or fluorine. The radical R1 preferably signify hydrogen or a methyl, ethyl or propargyl group, the radicals for R2 preferably signify hydrogen or a methyl, allyl or an n-butyl group. C compounds represented by the above structural formula may be produced by reacting a compound represented by the formula SPC2 With a compound having the formula Y -- Cm H2m -- R3, one of X and Y signifying the substituent R2 -- NH -- and the other signifying a halogen atom, preferably a bromine or chlorine atom, so as to form the above specified benzophenone derivative with the elimination of H -- Hal, R1, R2, R3, n and m being as defined above, and the rings A and B being optionally substituted as discussed above. The hydrogen halide which is eliminated is advantageously bound by the addition of an acid-binding agent, as for example, a molar excess of the amine used in the reaction or, for example, triethylamine, dimethylaniline, potassium or sodium carbonate or sodium bicarbonate. The reaction is carried out in a suitable solvent, preferably at an elevated temperature, typically the reflux temperature of the solvent used.