59082-25-6Relevant articles and documents
Copper/GanPhos-Catalyzed 1,3-Dipolar Cycloaddition of Azo?-methine Ylides: An Efficient Access to Chiral Pyrrolidine Spirocycles
Gan, Zhenjie,Li, Ke,Zhang, Hui,Li, Er-Qing
supporting information, p. 1331 - 1340 (2020/11/30)
A highly efficient copper/GanPhos-catalyzed 1,3-dipolar cyclo?-addition?-of azomethine ylides is reported. This viable transformation provides a series of optically active spiro[dihydronaphthalene-2,3′-pyrrolidine]s, bearing one spiro quaternary and three tertiary stereogenic centers, in good yields and with high ee values. This protocol features high diastereo- A nd enantioselectivity, broad substrate scope and mild reaction conditions.
Novel 1-tetralone chalcone and composition for preventing or treating inflammatory disease comprising the same as active ingredient
-
Paragraph 0178-0181, (2021/01/29)
Novel 1 -tetralone chalcone derivatives, 1-tetralone alone alone alone alone. A composition containing 6 - amino -1 - tetralone chalcone derivatives and 6-amino-1-tetralone alone alone alone alone is provided to systematically design 32 halogenated 1 -tet
A simple iron-catalyst for alkenylation of ketones using primary alcohols
Sk, Motahar,Kumar, Ashish,Das, Jagadish,Banerjee, Debasis
, (2020/04/10)
Herein, we developed a simple iron-catalyzed system for the α-alkenylation of ketones using primary alcohols. Such acceptor-less dehydrogenative coupling (ADC) of alcohols resulted in the synthesis of a series of important α,β-unsaturated functionalized ketones, having aryl, heteroaryl, alkyl, nitro, nitrile and trifluoro-methyl, as well as halogen moieties, with excellent yields and selectivity. Initial mechanistic studies, including deuterium labeling experiments, determination of rate and order of the reaction, and quantitative determination of H2 gas, were performed. The overall transformations produce water and dihydrogen as byproducts.
