59084-07-0

Upstream product

• 56243-25-5 1-benzyl-4-cyano-4-phenylpiperidine 

Downstream Products

• 1207203-28-8 1-({5-(2-chlorophenyl)-4-[4-(3-hydroxypropoxy)phenyl]thien-2-yl}carbonyl)-4-phenylpiperidine-4-carboxamide 
• 1207203-01-7 1-({5-(2-chloro-4-fluorophenyl)-4-[4-(3-hydroxypropoxy)phenyl]-2-thienyl}carbonyl)-4-phenylpiperidine-4-carboxamide 
• 1207202-97-8 4-{5-[(4-carbamoyl-4-phenylpiperidin-1-yl)carbonyl]-2-(2-chlorophenyl)thien-3-yl}phenyl propane-1-sulphonate 
• 1207202-96-7 1-{[5-(2,4-dichlorophenyl)-4-{4-[(4-hydroxybutyl)sulphonyl]phenyl}-2-thienyl]carbonyl}-4-phenylpiperidine-4-carboxamide 
• 1207203-52-8 1-{[4-(4-bromophenyl)-5-(2,4-dichlorophenyl)thien-2-yl]carbonyl}-4-phenylpiperidine-4-carboxamide 
• 1207203-45-9 C₃₃H₃₂Cl₂N₂O₆S₂ 
• 1207203-05-1 1-{[5-(2-Chloro-4-fluorophenyl)-4-{4-[3-(methylsulphonyl)propoxy]phenyl}thien-2-yl]carbonyl}-4-phenylpiperidine-4-carboxamide 
• 1207203-04-0 1-{[5-(2-Chloro-4-fluorophenyl)-4-{4-[3-(methylthio)propoxy]phenyl}thien-2-yl]carbonyl-}4-phenylpiperidine-4-carboxamide 
• 1207203-63-1 1-{[5-(2-Chloro-4-fluorophenyl)-4-{4-[3-(tetrahydro-2H-pyran-2-yl oxy)prop oxy]phenyl}thien-2-yl]carbonyl}-4-phenylpiperidine-4-carboxamide 
• 1207203-00-6 1-{[5-(2,4-Dichlorophenyl)-4-{4-[(4,4,4-trifluorobutyl)sulphonyl]phenyl}thien-2-yl]carbonyl}-4-phenylpiperidine-4-carboxamide 
• 1207202-99-0 1-{[5-(2,4-Dichlorophenyl)-4-{4-[(4,4,4-trifluorobutyl)thio]phenyl}thien-2-yl]carbonyl}-4-phenylpiperidine-4-carboxamide 
• 1207202-98-9 4-{5-[(4-Carbamoyl-4-phenylpiperidin-1-yl)carbonyl]-2-(2-chlorophenyl)thien-3-yl}phenyl 3,3,3-trifluoropropane-1-sulphonate 
• 1207203-56-2 1-{[5-(2-Chlorophenyl)-4-(4-hydroxyphenyl)thien-2-yl]carbonyl}-4-phenylpiperidine-4-carboxamide 
• 1207203-55-1 1-{[5-(2-Chlorophenyl)-4-(4-methoxyphenyl)thien-2-yl]carbonyl}-4-phenylpiperidine-4-carboxamide 

Relevant academic research and scientific papers

THIOPHENE-2-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF

The subject matter of the invention is compounds corresponding to formula (I), in which: R1 and R2, together with the nitrogen atom to which they are attached, constitute a saturated heterocyclic radical containing from 4 to 7 atoms, which is preferably substituted; one of the two substituents R3 and R6 is a group Y-A-R9; Y is an oxygen atom or an —S(O)n′—, or —OSO2 group; A is an unsubstituted (C1-C4) alkylene group; R9 is an —OR19, —CH3, —NR19R20, —CONR19R20, —NR15COR19, —S(O)nR21, or —NR13SO2R21 group; —R10 is a hydrogen atom or a (C1-C4) alkyl group. The present invention also relates to the methods of preparation and the therapeutic uses of the compounds of formula (I).