591-77-5

Usage

Uses

Used in Chemical Synthesis:
1,4-Diaminopentane is used as a key intermediate in the chemical synthesis for the production of nylon-4,6, a type of synthetic polymer known for its strength and versatility in various applications, including textiles and industrial materials.
Used in the Production of Polyurethane:
As a precursor, 1,4-Diaminopentane plays a crucial role in the creation of polyurethane, a versatile polymer used in the production of flexible and rigid foams, coatings, adhesives, and elastomers.
Used in Pharmaceutical Industry:
1,4-Diaminopentane is utilized in the pharmaceutical sector for its potential role in the development of new drugs and therapeutic agents, particularly in the area of cancer treatment.
Used in Agricultural Industry:
In agriculture, 1,4-Diaminopentane finds applications in the development of biostimulants and other products that enhance crop growth and productivity.
Used in Personal Care Products:
1,4-Diaminopentane is also used in the formulation of personal care products, such as cosmetics and skincare, due to its properties that can contribute to product efficacy and performance.
Used in Medical Research:
1,4-Diaminopentane has been studied for its potential as a biomarker for various diseases, offering insights into diagnostic and prognostic applications in the medical field.
Used in Cancer Treatment Research:
1,4-Diaminopentane has been investigated for its role in the treatment of cancer, with ongoing research exploring its potential to target and inhibit cancer cell growth and proliferation.

Upstream product

• 927-56-0 levulinonitrile 
• 1632-76-4 3-methylpyridazine 
• 89789-58-2 4-hydroxyimino-pentanal oxime 
• 636-41-9 2-methyl-1H-pyrrole 
• 1003-29-8 2-pyrrole aldehyde 
• 626-95-9 1,4-Pentanediol 
• 626-87-9 1,4-dibromopentane 
• 99595-69-4 1,4-bis(azido)pentane 

Downstream Products

• 62146-62-7 (4-aminobutyl)carbamic acid benzyl ester 
• 1421971-12-1 C₂₂H₃₅N₃O₆ 
• 1421971-13-2 C₂₆H₄₃N₃O₈ 
• 1421971-15-4 C₂₁H₃₃Cl₂N₃O₄ 
• 1421971-08-5 C₃₀H₃₇Cl₃N₄O₄ 
• 1421971-11-0 C₂₂H₃₃N₃O₈ 
• 4298-14-0 N,N-Dideethylchloroquine 
• 701255-53-0 tert-butyl (4-aminopentyl)carbamate 
• 1246467-39-9 N-benzyl-1-(3-(dimethylamino)propyl)-2-methyl-5-oxopyrrolidine-2-carboxamide 
• 1246467-43-5 N-cyclohexyl-1-(3-(dimethylamino)propyl)-2-methyl-5-oxopyrrolidine-2-carboxamide 
• 89789-76-4 (4-Benzyloxycarbonylamino-pentyl)-carbamic acid benzyl ester 

Relevant academic research and scientific papers

Reinvestigating Old Pharmacophores: Are 4-Aminoquinolines and Tetraoxanes Potential Two-Stage Antimalarials?

The syntheses and antiplasmodial activities of various substituted aminoquinolines coupled to an adamantane carrier are described. The compounds exhibited pronounced in vitro and in vivo activity against Plasmodium berghei in the Thompson test. Tethering a fluorine atom to the aminoquinoline C(3) position afforded fluoroaminoquinolines that act as intrahepatocytic parasite inhibitors, with compound 25 having an IC50 = 0.31 μM and reducing the liver load in mice by up to 92% at 80 mg/kg dose. Screening our peroxides as inhibitors of liver stage infection revealed that the tetraoxane pharmacophore itself is also an excellent liver stage P. berghei inhibitor (78: IC50 = 0.33 μM). Up to 91% reduction of the parasite liver load in mice was achieved at 100 mg/kg. Examination of tetraoxane 78 against the transgenic 3D7 strain expressing luciferase under a gametocyte-specific promoter revealed its activity against stage IV-V Plasmodium falciparum gametocytes (IC50 = 1.16 ± 0.37 μM). To the best of our knowledge, compounds 25 and 78 are the first examples of either an 4-aminoquinoline or a tetraoxane liver stage inhibitors.

COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER

The disclosures herein provide compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, enantiomers, stereoisomers, solvates, and hydrates thereof. These salts may be formulated as pharmaceutical compositions. The pharmaceutical compositions may be formulated for non-invasive oral administration, invasive, intravenous, transdermal administration, or injection. Such compositions may be used to treatment of cancer and its metastasis or its associated complications.

Reduction of Heterocycles with Nickel-Aluminum Alloy

Pyrazines, pyridazines, isoxazoles, oxazole, 4-methylpyrimidine, and indole are reduced by nickel-aluminum alloy in potassium hydroxide solution.The reaction is simple to carry out and does not require special apparatus or hydrogen atmospheres.The products were the fully hydrogenated species although benzene rings were not attacked. 4-Methylpyrimidine gave 1,3-diaminobutane and oxazole gave 2-(methylamino)ethanol.It was found that the reaction frequently exhibited an induction period.