59104-19-7 Usage
Uses
Used in Pharmaceutical Development:
2-(4-Chloro-phenoxy)-acetamidine hydrochloride is utilized as a pharmaceutical agent for its potential therapeutic effects in treating various diseases. Its ability to inhibit NHE1 makes it a candidate for conditions where the regulation of intracellular pH is critical, such as cancer, cardiovascular disorders, and inflammatory conditions.
Used in Cancer Treatment:
In the field of oncology, 2-(4-Chloro-phenoxy)-acetamidine hydrochloride is used as a potential therapeutic agent for its role in modulating the activity of NHE1, which has been implicated in tumor progression and resistance to chemotherapy. By inhibiting NHE1, the compound may help to reduce tumor growth and increase the effectiveness of other cancer treatments.
Used in Cardiovascular Research:
2-(4-Chloro-phenoxy)-acetamidine hydrochloride is employed in cardiovascular research to study the role of NHE1 in heart diseases and conditions related to abnormal pH regulation. Its inhibitory effect on NHE1 could provide insights into the development of new treatments for heart failure and other cardiovascular disorders.
Used in Inflammatory Disease Management:
In the context of inflammatory diseases, 2-(4-Chloro-phenoxy)-acetamidine hydrochloride is used to explore its potential in managing inflammation by targeting NHE1. Since NHE1 is involved in the inflammatory response, inhibiting its activity could help in reducing inflammation and associated symptoms.
Used in Laboratory Research:
As a hydrochloride salt, 2-(4-Chloro-phenoxy)-acetamidine hydrochloride is commonly used in laboratory research settings for studying the mechanisms of action and potential applications of NHE1 inhibitors. Researchers use 2-(4-CHLORO-PHENOXY)-ACETAMIDINE HCL to investigate the role of NHE1 in various biological processes and disease states.
Used in Enhancing Chemotherapy Efficacy:
2-(4-Chloro-phenoxy)-acetamidine hydrochloride is also being investigated for its potential to enhance the efficacy of chemotherapy drugs. By inhibiting NHE1, the compound may increase the sensitivity of cancer cells to chemotherapy, improving treatment outcomes and potentially overcoming drug resistance in cancer therapy.
Check Digit Verification of cas no
The CAS Registry Mumber 59104-19-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,9,1,0 and 4 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 59104-19:
(7*5)+(6*9)+(5*1)+(4*0)+(3*4)+(2*1)+(1*9)=117
117 % 10 = 7
So 59104-19-7 is a valid CAS Registry Number.
InChI:InChI=1/C8H9ClN2O.ClH/c9-6-1-3-7(4-2-6)12-5-8(10)11;/h1-4H,5H2,(H3,10,11);1H
59104-19-7Relevant academic research and scientific papers
EFFECT OF REMOTE HETEROATOM SUBSTITUENTS ON STEREOCHEMISTRY IN 1,2 H MIGRATION TO DIVALENT CARBON. EVIDENCE FOR " NEGATIVE " HYPERCONJUGATION OF CARBENE LONE PAIR
Tomioka, Hideo,Hayashi, Norihiro,Inoue, Noboru,Izawa, Yasuji
, p. 1651 - 1654 (2007/10/02)
Aryloxymethylchlorocarbene generated by photolysis of the corresponding diazirine afforded α-aryloxy-β-chloroalkene.The thermodynamically less stable Z-products are the major isomers and its content becomes dominant as more electron-withdrawing groups are
