59104-79-9

Usage

Uses

Used in Organic Synthesis:
1,1-dibromoheptane is used as a reagent in organic synthesis for its ability to participate in various chemical reactions such as nucleophilic substitution and cross-coupling reactions. Its reactivity allows for the preparation of a wide range of organic compounds.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 1,1-dibromoheptane is used as a key intermediate in the synthesis of various drugs. Its versatility as a building block contributes to the development of new medicinal compounds.
Used in Agrochemical Production:
1,1-dibromoheptane is also utilized in the agrochemical sector, where it serves as an intermediate in the production of various agrochemicals, contributing to the development of effective crop protection agents.
Used in the Preparation of Surfactants:
As a strong alkylating agent, 1,1-dibromoheptane is used in the synthesis of surfactants, which are essential in the formulation of detergents, emulsifiers, and other products that require the reduction of surface tension between two different substances.
Used in the Preparation of Lubricants:
1,1-dibromoheptane is employed in the production of lubricants, where its chemical properties contribute to the development of high-quality lubricating oils and greases for various industrial applications.
Used in Specialty Chemicals Production:
1,1-dibromoheptane is used as an intermediate in the preparation of specialty chemicals, which are often used in niche applications requiring specific chemical properties, such as in the coatings, adhesives, and sealants industries.

InChI:InChI=1/C7H14Br2/c1-2-3-4-5-6-7(8)9/h7H,2-6H2,1H3

Upstream product

• 111-71-7 heptanal 
• 111-68-2 1-Heptylamine 

Downstream Products

• 89942-12-1 (E)/(Z)-1-bromo-1-heptene 
• 628-71-7 1-Heptyne 
• 141676-16-6 1,4,5-triphenyl-2-(7-bromoheptyloxy)imidazole 
• 141676-12-2 sodium 7-(1,4,5-triphenylimidazol-2-yloxy)heptanesulphonate 
• 1301263-96-6 rac-(3aR,6aS)-5-hexyl-2-phenyl-5-(1-phenylvinyl)-octahydro-cyclopenta[c]pyrrole 
• 1301263-79-5 C₂₂H₃₈O₂ 
• 1301264-04-9 2-hexylidene-2,3,3a,4,9,9a-hexahydro-1Hcyclopenta[b]naphthalene 
• 1301264-05-0 2-hexyl-3a,4,9,9a-tetrahydro-1Hcyclopenta[b]naphthalene 
• 1301742-17-5 rac-(3aS,6aR)-2-benzyl-5-hexyl-5-(1-phenylvinyl)octahydrocyclopenta[c]pyrrole 

Relevant academic research and scientific papers

Development of the First Low Nanomolar Liver Receptor Homolog-1 Agonist through Structure-guided Design

As a key regulator of metabolism and inflammation, the orphan nuclear hormone receptor, liver receptor homolog-1 (LRH-1), has potential as a therapeutic target for diabetes, nonalcoholic fatty liver disease, and inflammatory bowel diseases (IBD). Discovery of LRH-1 modulators has been difficult, in part due to the tendency for synthetic compounds to bind unpredictably within the lipophilic binding pocket. Using a structure-guided approach, we exploited a newly discovered polar interaction to lock agonists in a consistent orientation. This enabled the discovery of the first low nanomolar LRH-1 agonist, one hundred times more potent than the best previous modulator. We elucidate a novel mechanism of action that relies upon specific polar interactions deep in the LRH-1 binding pocket. In an organoid model of IBD, the new agonist increases expression of LRH-1-controlled steroidogenic genes and promotes anti-inflammatory gene expression changes. These studies constitute major progress in developing LRH-1 modulators with potential clinical utility.

MODULATORS OF LIVER RECEPTOR HOMOLOGUE 1 (LRH-1) AND USES

This disclosure relates to modulators of liver receptor homologue 1 (LRH-1) and methods of managing disease and conditions related thereto. In certain embodiments, modulators are derivatives of hexahydropentalene. In certain embodiments, this disclosure r

Copper-Catalyzed Double C(sp3)-Si Coupling of Geminal Dibromides: Ionic-to-Radical Switch in the Reaction Mechanism

A method for converting geminal dibromides into 1,1-disilylated alkanes is reported. The reaction is promoted by a copper(I) catalyst generated in situ from CuBr·SMe2 as a precatalyst and 4,4′-di-tert-butyl-2,2′-bipyridine (dtbpy) as a ligand. A Si-B reagent is used as the silicon pronucleophile. It is shown that the two C(sp3)-Si bond-forming events differ in mechanism, with the first being ionic and the second being radical.

Conversion of Aldehydes into 1,1-Dibromoalkanes

Aliphatic and aromatic aldehydes have been converted into 1,1-dibromoalkyl derivatives using a 1:1 mixture of triphenyl phosphite and bromine as reagent.