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59108-90-6

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59108-90-6 Usage

Description

1H-INDOLE-3-CARBOTHIOIC ACID AMIDE, commonly referred to as indole-3-carbinol (I3C), is a naturally occurring compound predominantly found in cruciferous vegetables such as broccoli, cabbage, and kale. It is celebrated for its potential health benefits, which include anti-cancer properties, support for hormone balance, and promotion of detoxification pathways within the body. I3C also exhibits antioxidant and anti-inflammatory effects, positioning it as a promising compound for the prevention and treatment of a variety of diseases. Furthermore, it has been studied for its potential to promote healthy liver function and support the immune system, making 1H-INDOLE-3-CARBOTHIOIC ACID AMIDE a compound of significant interest for its natural health-promoting properties.

Uses

Used in Health and Nutrition Industry:
1H-INDOLE-3-CARBOTHIOIC ACID AMIDE is used as a dietary supplement for its potential health benefits, including its anti-cancer properties. It supports hormone balance and promotes detoxification pathways, which can contribute to overall health and well-being.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 1H-INDOLE-3-CARBOTHIOIC ACID AMIDE is used as a subject of research for its potential role in the development of treatments for various diseases. Its antioxidant and anti-inflammatory effects are of particular interest for conditions where these properties could provide therapeutic benefits.
Used in Immune System Support:
1H-INDOLE-3-CARBOTHIOIC ACID AMIDE is used as an immune system supporter due to its potential to enhance the body's natural defenses against illness and infection.
Used in Liver Function Promotion:
In the realm of liver health, 1H-INDOLE-3-CARBOTHIOIC ACID AMIDE is utilized for its potential to promote liver function, which is crucial for the body's detoxification processes and overall metabolic health.

Check Digit Verification of cas no

The CAS Registry Mumber 59108-90-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,9,1,0 and 8 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 59108-90:
(7*5)+(6*9)+(5*1)+(4*0)+(3*8)+(2*9)+(1*0)=136
136 % 10 = 6
So 59108-90-6 is a valid CAS Registry Number.

59108-90-6 Well-known Company Product Price

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  • Alfa Aesar

  • (H54438)  Indole-3-thiocarboxamide, 97%   

  • 59108-90-6

  • 250mg

  • 941.0CNY

  • Detail
  • Alfa Aesar

  • (H54438)  Indole-3-thiocarboxamide, 97%   

  • 59108-90-6

  • 1g

  • 3009.0CNY

  • Detail

59108-90-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 1H-indole-3-carbothioamide

1.2 Other means of identification

Product number -
Other names indole-3-thioamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:59108-90-6 SDS

59108-90-6Relevant articles and documents

-

Suvorov et al.

, (1976)

-

Aerobic Visible-Light Induced Intermolecular S?N Bond Construction: Synthesis of 1,2,4-Thiadiazoles from Thioamides under Photosensitizer-Free Conditions

Wang, Hui,Xie, Shihua,Zhu, Hongjun,Zhuo, Liang

supporting information, p. 3398 - 3402 (2021/06/25)

Aerobic visible-light induced intermolecular S?N bond construction has been achieved without the addition of photosensitizer, metal, or base. With this strategy, 1,2,4-thiadiazoles can be obtained from thioamides. Preliminary mechanistic investigation suggested that the excited state of thioamides undergoes a single-electron-transfer (SET) process to afford thioamidyl radicals, which can be further transformed into a 1,2,4-thiadiazole through desulfurization and oxidative cyclization. The reaction has good functional group tolerance and represents a green method for the construction of S?N bonds.

Synthesis and antitumor activity of new thiazole nortopsentin analogs

Attanzio, Alessandro,Barraja, Paola,Carbone, Anna,Cascioferro, Stella,Cirrincione, Girolamo,Diana, Patrizia,Montalbano, Alessandra,Parrino, Barbara,Spanò, Virginia,Tesoriere, Luisa

, (2017/01/04)

New thiazole nortopsentin analogs in which one of the two indole units was replaced by a naphthyl and/or 7-azaindolyl portion, were conveniently synthesized. Among these, three derivatives showed good antiproliferative activity, in particular against MCF7 cell line, with GI50 values in the micromolar range. Their cytotoxic effect on MCF7 cells was further investigated in order to elucidate their mode of action. Results showed that the three compounds act as pro-apoptotic agents inducing a clear shift of viable cells towards early apoptosis, while not exerting necrotic effects. They also caused cell cycle perturbation with significant decrease in the percentage of cells in the G0/G1 and S phases, accompanied by a concomitant percentage increase of cells in the G2/M phase, and appearance of a subG1-cell population.

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