59114-87-3

Basic information

• Product Name: 2-Propenoyl chloride, 3-(3-bromophenyl)-, (2E)-
• CAS NO: 59114-87-3
• Molecular Formula: C9H6BrClO
• Molecular Weight: 245.503
• Mol File: 59114-87-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-Propenoyl chloride, 3-(3-bromophenyl)-, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoyl chloride, 3-(3-bromophenyl)-, (2E)-(59114-87-3)
• EPA Substance Registry System: 2-Propenoyl chloride, 3-(3-bromophenyl)-, (2E)-(59114-87-3)

Safety Data

• Hazardous Substances Data: 59114-87-3(Hazardous Substances Data)

Upstream product

• 97985-66-5 (E)-3-(3-bromophenyl)acrylaldehyde 
• 14473-91-7 3-bromocinnamic acid 

Downstream Products

• 100098-61-1 (E)-3-bromo-N-(2-hydroxy-1,1-dimethylethyl) cinnamamide 
• 918287-58-8 (S)-N-[3-(3-bromo)phenyl-2-(E)-propenoyl]-4-isopropyl-1,3-oxazolidine-2-thione 
• 1034558-65-0 (E)-1-bromo-3-(2-isocyanatovinyl)benzene 
• 78974-20-6 Sodium; (2S,5R,6R)-6-{3-[(E)-2-(3-bromo-phenyl)-vinyl]-ureido}-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate 
• 1312679-76-7 5-bromo-2-{[(2E)-3-(3-bromophenyl)prop-2-enoyl]amino}benzamide 
• 1312679-68-7 (E)-2-(3-(3-bromophenyl)acrylamido)-5-chlorobenzamide 
• 88618-53-5 methyl β-3,3'-dibromotruxinate 

Relevant articles and documents

Design, Synthesis, and Anticancer Activity of Cinnamoylated Barbituric Acid Derivatives

This work deals with the design and synthesis of 18 barbituric acid derivatives bearing 1,3-dimethylbarbituric acid and cinnamic acid scaffolds to find potent anticancer agents. The target molecules were obtained through Knoevenagel condensation and acylation reaction. The cytotoxicity was assessed by the MTT assay. Flowcytometry was performed to determine the cell cycle arrest, apoptosis, ROS levels and the loss of MMP. The ratios of GSH/GSSG and the MDA levels were determined by using UV spectrophotometry. The results revealed that introducing substitutions (CF3, OCF3, F) on the meta- of the benzyl ring of barbituric acid derivatives led to a considerable increase in the antiproliferative activities compared with that of corresponding ortho- and para-substituted barbituric acid derivatives. Mechanism investigation implied that the 1c could increase the ROS and MDA level, decrease the ratio of GSH/GSSG and MMP, and lead to cell cycle arrest. Further research is needed for structural optimization to enhance hydrophilicity, thereby improve the biological activity of these compounds.

Benzo[b]pyrano[3,2-h]acridin-7-one cinnamate compounds

A compound selected from those of formula (I): wherein: X and Y represent a group selected from hydrogen, halogen, alkoxy, nitro, cyano, alkyl, alkenyl, polyhaloalkyl and —NRaRb wherein Ra and Rb are as defined