Cas 591217-89-9,Benzoic acid, 4-[[([1,1'-biphenyl]-2-ylcarbonyl)amino]methyl]-

591217-89-9

Post Buying Request

Basic information

Product Name: Benzoic acid, 4-[[([1,1'-biphenyl]-2-ylcarbonyl)amino]methyl]-
Synonyms:
CAS NO:591217-89-9
Molecular Formula: C21H17NO3
Molecular Weight: 331.371
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: Benzoic acid, 4-[[([1,1'-biphenyl]-2-ylcarbonyl)amino]methyl]-(CAS DataBase Reference)
NIST Chemistry Reference: Benzoic acid, 4-[[([1,1'-biphenyl]-2-ylcarbonyl)amino]methyl]-(591217-89-9)
EPA Substance Registry System: Benzoic acid, 4-[[([1,1'-biphenyl]-2-ylcarbonyl)amino]methyl]-(591217-89-9)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 591217-89-9(Hazardous Substances Data)

Suppliers
Usage
Upstream product
Downstream Products
Article

591217-89-9 Suppliers

Recommended suppliers

591217-89-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 591217-89-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,9,1,2,1 and 7 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 591217-89:
(8*5)+(7*9)+(6*1)+(5*2)+(4*1)+(3*7)+(2*8)+(1*9)=169
169 % 10 = 9
So 591217-89-9 is a valid CAS Registry Number.

591217-89-9Upstream product

591217-89-9Downstream Products

591217-91-3 biphenyl-2-carboxylic acid 4-benzyloxycarbamoyl-benzylamide

591217-89-9Relevant academic research and scientific papers

A Dual Modulator of Farnesoid X Receptor and Soluble Epoxide Hydrolase to Counter Nonalcoholic Steatohepatitis

Schmidt, Jurema,Rotter, Marco,Weiser, Tim,Wittmann, Sandra,Weizel, Lilia,Kaiser, Astrid,Heering, Jan,Goebel, Tamara,Angioni, Carlo,Wurglics, Mario,Paulke, Alexander,Geisslinger, Gerd,Kahnt, Astrid,Steinhilber, Dieter,Proschak, Ewgenij,Merk, Daniel

supporting information, p. 7703 - 7724 (2017/10/06)

Nonalcoholic steatohepatitis arising from Western diet and lifestyle is characterized by accumulation of fat in liver causing inflammation and fibrosis. It evolves as serious health burden with alarming incidence, but there is no satisfying pharmacological therapy to date. Considering the disease's multifactorial nature, modulation of multiple targets might provide superior therapeutic efficacy. In particular, farnesoid X receptor (FXR) activation that revealed antisteatotic and antifibrotic effects in clinical trials combined with inhibition of soluble epoxide hydrolase (sEH) as anti-inflammatory strategy promises synergies. To exploit this dual concept, we developed agents exerting partial FXR agonism and sEH inhibitory activity. Merging known pharmacophores and systematic exploration of the structure-activity relationship on both targets produced dual modulators with low nanomolar potency. Extensive in vitro characterization confirmed high dual efficacy in cellular context combined with low toxicity, and pilot in vivo data revealed favorable pharmacokinetics as well as engagement on both targets in vivo.

Novel histone deacetylase inhibitors: N-hydroxycarboxamides possessing a terminal bicyclic aryl group

Uesato, Shinichi,Kitagawa, Manabu,Nagaoka, Yasuo,Maeda, Taishi,Kuwajima, Hiroshi,Yamori, Takao

, p. 1347 - 1349 (2007/10/03)

Utilizing tranexamic acid as a starting material, a series of N-hydroxycarboxamides were synthesized in order to seek new histone deacetylase (HDAC) inhibitors. Further structure optimization involving the replacement of the 1,4-cyclohexylene group with t

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 591217-89-9