591219-91-9

Upstream product

• 103-71-9 phenyl isocyanate 
• 591219-87-3 ethyl 3-phenylureido-2-benzofuran carboxylate 
• 39786-35-1 ethyl 3-aminobenzofuran-2-carboxylate 
• 591219-88-4 2-chloro-3-phenyl-3,4-dihydro-4-oxobenzofuro[3,2-d]pyrimidine 

Relevant academic research and scientific papers

Synthesis and biological activity of some benzofuro[3,2- d]pyrimidines

The condensation of ethyl 3-amino-2-benzofuran carboxylate (1) with phenyl isocyanate gave 3-phenylureido-2-benzofuran carboxylate (2), which upon treatment with phosphorus oxychloride gave 2-chloro-3-phenyl-3,4-dihydro-4-oxobenzofuro[3,2-d]pyrimidine (4). The reaction of 4 with alicyclic amines like piperidine and morpholine yielded 2-piperidino/morpholino compounds (5a and 5b, respectively). 2-Hydrazino-3- phenyl-3,4-dihydro-4-oxobenzofuro[3,-d]pyrimidine (6) obtained from 4 was subjected to reactions with different reagents. All compounds were screened for their antibacterial and antifungal activities.