59123-22-7Relevant articles and documents
Synthesis method of multi-configuration O-phenyl-serine compound
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Paragraph 0031-0036; 0211-0216, (2020/07/12)
The invention relates to a synthesis method of a multi-configuration O-phenyl-serine compound. The method comprises the following steps: (1) in the presence of a solvent, alkali and a palladium catalyst, reacting a compound shown as formula I and a compound shown as formula II under the protection of inert gas to obtain an intermediate compound; (2) carrying out deprotection reaction on the intermediate compound to prepare an O-phenyl-serine compound shown as formula III; wherein the structural formula of the compound shown as formula I is shown in the specification, the structural formula ofthe compound shown as formula II is shown in the specification, and the structural formula of the compound shown as formula III is shown in the specification, wherein in the formula I and formula III,R is one of H, alkyl, alkoxy and halogen. According to the synthesis method disclosed by the invention, the palladium catalyst is selected as the catalyst, so that the reaction of mono-substituted iodobenzene and multi-configuration N-tert-butyloxycarbonyl-serine methyl ester can be effectively catalyzed, the reaction is promoted, the reaction is simple and easy to operate, mild, low in toxicity,and high in product yield.
