5915-64-0

Basic information

• Product Name: 4-({3-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]phenyl}sulfonyl)morpholine
• Synonyms: 4-[3-(5-p-Tolyl-[1,3,4]oxadiazol-2-yl)-benzenesulfonyl]-morpholine; morpholine, 4-[[3-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]phenyl]sulfonyl]-
• CAS NO: 5915-64-0
• Molecular Formula: C₁₉H₁₉N₃O₄S
• Molecular Weight: 385.4369
• Mol File: 5915-64-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 596.3°C at 760 mmHg
• Flash Point: 314.4°C
• Density: 1.32g/cm³
• Vapor Pressure: 3.48E-14mmHg at 25°C
• Refractive Index: 1.599
• CAS DataBase Reference: 4-({3-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]phenyl}sulfonyl)morpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-({3-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]phenyl}sulfonyl)morpholine(5915-64-0)
• EPA Substance Registry System: 4-({3-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]phenyl}sulfonyl)morpholine(5915-64-0)

Safety Data

• Hazardous Substances Data: 5915-64-0(Hazardous Substances Data)

Upstream product

• 80321-11-5 morpholide of 1-hydroxy-3,7,11,15,19,23-hexamethyltetracosa-2Z,6Z,10Z,14E,18E,22-hexaen-4-sulfonic acid 
• 24163-93-7 farnesyl bromide 
• 669065-07-0 C₃₇H₆₀O₂ 
• 68690-47-1 1-methyl-4-{[(2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl]sulfonyl}benzene 
• 68690-51-7 all-trans-1-benzyloxy-3,7,11,15-tetramethyl-9-p-tolylsulfonyl-2,6,10,14-hexadecatetraene 
• 24034-73-9 Geranylgeraniol 
• 50848-64-1 2E,6E,10E-geranylgeranyl bromide 
• 68690-53-9 all-trans-1-benzyloxy-3,7,11,15,19,23-hexamethyl-9-(p-tolylsulfonyl)-2,6,10,14,18,22-tetracosahexaene 
• 80321-08-0 (2Z,6E,10E)-1-bromo-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraene 
• 22488-05-7 (2Z,6Z,10E,14E)-3,7,11,15,19-pentamethylicosa-2,6,10,14,18-pentaen-1-ol 
• 57784-25-5 (2Z,6Z,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-ol 
• 92464-88-5 (2Z,6Z,10Z)-12-Benzyloxy-2,6,10-trimethyl-dodeca-2,6,10-trien-1-ol 
• 92464-84-1 (4Z,8Z)-10-Benzyloxy-4,8-dimethyl-deca-4,8-dien-1-ol 
• 92464-86-3 ((4Z,8Z)-10-Benzyloxy-4,8-dimethyl-deca-4,8-dienyl)-triphenyl-phosphonium; iodide 

Downstream Products

• 5905-41-9 (2Z,6Z,10Z,14Z,18E,22E)-3,7,11,15,19,23,27-heptamethyltriaconta-2,6,10,14,18,22,26-heptaen-1-ol 
• 15639-69-7 solanesol 
• 92464-91-0 1-((2Z,6Z,10Z,14Z,18Z,22Z,26E,30E)-1-Benzyloxy-3,7,11,15,19,23,27,31,35-nonamethyl-hexatriaconta-2,6,10,14,18,22,26,30,34-nonaene-13-sulfonyl)-4-methyl-benzene 
• 92542-08-0 1-((2Z,6Z,10Z,14Z,18Z,22E,26E)-1-Benzyloxy-3,7,11,15,19,23,27,31-octamethyl-dotriaconta-2,6,10,14,18,22,26,30-octaene-9-sulfonyl)-4-methyl-benzene 
• 5905-42-0 betulaprenol-8 
• 68690-55-1 1-((2E,6E,10E,14Z,18E,22E,26E)-1-Benzyloxy-3,7,11,15,19,23,27,31-octamethyl-dotriaconta-2,6,10,14,18,22,26,30-octaene-9-sulfonyl)-4-methyl-benzene 
• 5905-42-0 all-trans-3,7,11,15,19,23,27,31-octamethyl-2,6,10,14,18,22,26,30-triacontaoctaen-1-ol 
• 68690-49-3 1-((2E,6E,10E,14Z,18E)-3,7,11,15,19,23-Hexamethyl-tetracosa-2,6,10,14,18,22-hexaene-1-sulfonyl)-4-methyl-benzene 

Relevant articles and documents

Modular synthesis of diphospholipid oligosaccharide fragments of the bacterial cell wall and their use to study the mechanism of moenomycin and other antibiotics

We present a flexible, modular route to GlcNAc-MurNAc-oligosaccharides that can be readily converted into peptidoglycan (PG) fragments to serve as reagents for the study of bacterial enzymes that are targets for antibiotics. Demonstrating the utility of these synthetic PG substrates, we show that the tetrasaccharide substrate lipid IV (3), but not the disaccharide substrate lipid II (2), significantly increases the concentration of moenomycin A required to inhibit a prototypical PG-glycosyltransferase (PGT). These results imply that lipid IV and moenomycin A bind to the same site on the enzyme. We also show the moenomycin A inhibits the formation of elongated polysaccharide product but does not affect length distribution. We conclude that moenomycin A blocks PG-strand initiation rather than elongation or chain termination. Synthetic access to diphospholipid oligosaccharides will enable further studies of bacterial cell wall synthesis with the long-term goal of identifying novel antibiotics.

GENERAL METHOD OF STEREOSPECIFIC SYNTHESIS OF NATURAL POLYPRENOLS. SYNTHESIS OF BETULAPRENOL-6, -7, -8, AND -9

A stereoselective synthesis of (Z,Z,Z)-12-benzyloxy-1-chloro-2,6,10-trimethyldodeca-2,6,10-triene was achieved starting from (Z,Z)-farnesol.All the components of betulaprenols were synthesized using the C15 block 3 and its lower homologue (C10 block) as t

SYNTHESIS OF (2Z,6Z,10Z,14E,18E)-FARNESYLFARNESOL

Nine-step synthesis of the title triterpenol from (E,E)-farnesol using a two-stage cis-C5-homologation procedure is described.