59155-63-4Relevant academic research and scientific papers
Preparation of γ,δ-unsaturated-β-ketoesters: Lewis acid-catalysed C[sbnd]H insertion of ethyl diazoacetate into α,β-unsaturated aldehydes
Gandhi, Hirenkumar,O'Sullivan, Timothy P.
, p. 3533 - 3535 (2017)
The synthesis of γ,δ-unsaturated-β-keto esters was achieved by the Lewis acid-catalysed direct C[sbnd]H insertion of an α-diazoester into various α,β-substituted-unsaturated aldehydes. C[sbnd]H insertion of ethyl diazoacetate into alkyl- and aryl-substituted α,β-unsaturated aldehydes was performed under mild conditions to afford the corresponding γ,δ-unsaturated-β-keto esters in moderate to high yields as a mixture of keto/enol tautomers.
Pharmaceutical compositions containing 5-phenyl-1,3-dioxoalkenyl compounds
-
, (2008/06/13)
This invention relates to pharmaceutical compositions containing a class of 5-phenyl-1,3-dioxoalkenyl compounds useful as inhibitors of leukotriene biosynthesis and thus useful in the treatment of conditions associated with leukotrienes. This invention al
