59155-84-9

Usage

Uses

Used in Pharmaceutical Synthesis:
METHYL 2-(2-PROPYNYLOXY)BENZENECARBOXYLATE is used as a key intermediate in the synthesis of pharmaceuticals for its ability to participate in various organic reactions, contributing to the development of new drugs.
Used in Agrochemical Production:
METHYL 2-(2-PROPYNYLOXY)BENZENECARBOXYLATE is also utilized in the production of agrochemicals, where its reactivity aids in the creation of effective substances for agricultural applications.
Used in Fragrance and Flavoring Industry:
METHYL 2-(2-PROPYNYLOXY)BENZENECARBOXYLATE is used as a building block in the synthesis of fragrances and flavorings, capitalizing on its reactivity to produce a wide range of scents and tastes.
Used in Organic Chemistry Research:
Due to its high reactivity, METHYL 2-(2-PROPYNYLOXY)BENZENECARBOXYLATE is employed in organic chemistry research to explore new reaction pathways and develop innovative synthetic methods.

InChI:InChI=1/C11H10O3/c1-3-8-14-10-7-5-4-6-9(10)11(12)13-2/h1,4-7H,8H2,2H3

Upstream product

• 106-96-7 propargyl bromide 
• 119-36-8 methyl salicylate 
• 69-72-7 salicylic acid 

Downstream Products

• 55582-31-5 2-(prop-2-yn-1-yloxy)benzoic acid 
• 1615201-27-8 methyl 2-((1-(4-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)phenyl)-1H-1,2,3-triazol-4-yl)methoxy)benzoate 
• 1615201-37-0 methyl 2-((1-(4-((6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)phenyl)-1H-1,2,3-triazol-4-yl)methoxy)benzoate 
• 1620300-91-5 2-chloroethyl2-(prop-2-yn-1-yloxy)benzoate 
• 1620300-63-1 2,3-dihydro-3-methyliden-5H-1,4-benzodioxepin-5-one 
• 1620300-62-0 2-[3’-(p-nitrophenyl)prop-2’-ynyloxyl]benzoic acid 
• 1620300-87-9 methyl 2-[[3-(4-methoxyphenyl)-2-propyn-1-yl]oxy]benzoate 
• 1620300-89-1 methyl2-[3’-(p-nitrophenyl)prop-2’-ynyloxyl]benzoate 

Relevant academic research and scientific papers

Design and synthesis of triazole conjugated novel 2,5-diaryl substituted 1,3,4-oxadiazoles as potential antimicrobial and anti-fungal agents

A series of triazole conjugated novel 2,5-diaryl 1,3,4-oxadiazole derivatives 8a-q are efficiently synthesized starting from methyl salicylate. All the synthesized compounds were characterized based on their 1H NMR, 13C NMR, Mass and

Design and synthesis, biological evaluation of bis-(1,2,3- and 1,2,4)-triazole derivatives as potential antimicrobial and antifungal agents

A new series of bis-1,2,3- and 1,2,4-triazoles (10a-m) were designed and efficiently synthesized using methyl salicylate as potential antimicrobial agents. All compounds were characterized by their proton & 13C NMR, IR, Mass spectral data, and

Synthesis, in silico Pharmacokinetic and Antimicrobial Studies of Oxovanadium(V) Complexes with 2-(4-((2-(Carboxy)phenoxy) methyl)-1H-1,2,3-triazol-1-Yl)Benzoic Acid

New Vanadium(V) complexes with new ligand 2-(4-((2-(carboxy) phenoxy) methyl)-1H-1,2,3triazol-1-yl)benzoic acid (L1) has been synthesized and characterized by different analytical techniques such as elemental analyzer, 1H NMR, UV-Vis

Synthesis and neuroprotective effects of novel chalcone-triazole hybrids

The development of novel neuroprotective agents is urgently needed for the treatment of neurodegenerative diseases, affecting aging individuals worldwide. In this study, a new set of chalcone-triazole hybrids (6a-g) was synthesized and evaluated for their

Gold promoted arylative cyclization of alkynoic acids with arenediazonium salts

Alkynoic acids derived from salicylic acid and analogues undergo arylative cyclization with arenediazonium salts promoted by gold in the absence of external ligands. The reaction is thermally induced and proceeds even in the absence of light. A difference in regioselectivity has been found compared with that observed in the cycloisomerization process of the same type of compounds.

Synthesis of Tetrasubstituted α,β-Unsaturated Aldehydes via Radical 1,4-Aryl Migration/Trifluoromethylthiolation Cascade Reaction of Aryl Propynyl Ethers

A one-pot synthesis of tetrasubstituted acrylaldehydes via difunctionalization of aryl propynyl ethers has been achieved, which involves a trifluoromethylthiolation process and a radical 1,4-aryl migration from oxygen to carbon. The reaction shows excellent conversion of aryl propynyl ethers into trifluoromethyl-containing α,β-unsaturated aldehydes through a radical pathway. (Figure presented.).

Palladium-catalyzed cyclization of alkynoic acids to form vinyl dioxanones bearing a quaternary allylic carbon

A palladium-catalyzed intramolecular reaction of carboxylic acids and alkynes in a novel cyclization manner was developed. This unique cyclization efficiently provided a wide range of complex ring systems-vinyl dioxanones bearing a quaternary allylic carbon. Mechanistic studies suggest an allenyl carboxylate as an intermediate.

Natural-Product-Inspired Aminoepoxybenzoquinones Kill Members of the Gram-Negative Pathogen Salmonella by Attenuating Cellular Stress Response

Gram-negative bacteria represent a challenging task for antibacterial drug discovery owing to their impermeable cell membrane and restricted uptake of small molecules. We herein describe the synthesis of natural-product-derived epoxycyclohexenones and explore their antibiotic activity against several pathogenic bacteria. A compound with activity against Salmonella Typhimurium was identified, and the target enzymes were unraveled by quantitative chemical proteomics. Importantly, two protein hits were linked to bacterial stress response, and corresponding assays revealed an elevated susceptibility to reactive oxygen species upon compound treatment. The consolidated inhibition of these targets provides a rationale for antibacterial activity and highlights epoxycyclohexenones as natural product scaffolds with suitable properties for killing Gram-negative Salmonella.

TRIAZOLOPYRIMIDINE COMPOUNDS AND USES THEREOF

A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating a PRC2-mediated disease or disorder: wherein R1, R2, R3, R4, R5, and n are as defined herein.

Silver(I) and gold(I)-promoted synthesis of alkylidene lactones and 2H-chromenes from salicylic and anthranilic acid derivatives

Ag(I) and Au(I) efficiently catalyze the cycloisomerization of terminal alkynoic acids into methylene seven-membered ring lactones. Depending on the metal, divergent reaction pathways were found for non terminal alkynoic acids. While Ag(I) led to lactones, Au(I) led to 2H-chromenes coming from the hydroarylation of the alkyne.