59158-71-3

Upstream product

• 614-47-1 1,3-diphenyl-propen-3-one 
• 82631-94-5 (+/-)-1,3-diphenyltrimethylene bismethanesulphonate 
• 14371-10-9 (E)-3-phenylpropenal 
• 229018-04-6 (+)-(R,R)-1,3-diphenyl-1,3-propanediazide 
• 62668-02-4 (E)-1,3-diphenyl-2-propen-1-ol 
• 623932-48-9 (S,S)-methanesulfonyloxy-1,3-diphenylpropane-1,3-diol 
• 132014-29-0 (S)-(E)-1,3-diphenylprop-2-en-1-ol 
• 108391-15-7 (1S,3S)-1,3-diphenylpropane-1,3-diol 
• 140867-97-6 (3R^*,5R^*)-1-tert-butoxycarbonyl-3,5-diphenylpyrazolidine 
• 140867-96-5 1-tert-butoxycarbonyl-4,5-dihydro-5-phenylpyrazole 
• 936-47-0 5-phenyl-4,5-dihydro-1H-pyrazole 
• 5381-86-2 (+/-)-(RS,RS)-1,3-diphenyl-1,3-propanediol 
• 142634-65-9 (3R,5R)-3,5-Diphenyl-pyrazolidine 
• 229018-00-2 (-)-(R,S,R)-1-hydroxy-2,3-epoxy-1,3-diphenylpropane 

Downstream Products

• 59132-37-5 (+)-(1S,3S)-1,3-diphenyl-1,3-propanediamine 
• 140867-98-7 (1R^*,3R^*)-N,N'-bisformyl-1,3-diphenyl-1,3-propanediamine 
• 140888-99-9 (1R^*,3R^*)-N,N'-bis(2,4,6-trimethylphenylmethyl)-1,3-diphenyl-1,3-propanediamine 
• 140868-03-7 (1R^*,3R^*)-N,N'-bis(2,2-dimethylpropyl)-1,3-diphenyl-1,3-propanediamine 
• 140868-01-5 (1R^*,3R^*)-N,N'-diethyl-1,3-diphenyl-1,3-propanediamine 
• 140868-00-4 (1R^*,3R^*)-N,N'-dimethyl-1,3-diphenyl-1,3-propanediamine 
• 135613-89-7 (1R^*,3R^*)-N,N'-dibenzyl-1,3-diphenyl-1,3-propanediamine 
• 140868-02-6 (1R^*,3R^*)-N,N'-bis(1-methylethyl)-1,3-diphenyl-1,3-propanediamine 
• 135614-40-3 (1R,3R)-1,3-Diphenyl-N,N'-bis-[1-phenyl-meth-(E)-ylidene]-propane-1,3-diamine 
• 140867-99-8 (1R^*,3R^*)-N,N'-bisacetyl-1,3-diphenyl-1,3-propanediamine 

Relevant academic research and scientific papers

Synthesis of novel C2-symmetric ligands based on (R,R)- and (S,S)- diphenyl-1,3-propanediol

A range of novel C2-symmetric dioxygen and dinitrogen ligands can readily be obtained through the interconversion of the parent 1,3-diphenyl- 1,3-propanediol enantiomers which are, in turn, accessed in good yields via a Sharpless asymmetric epoxidative resolution.

Addition of Diethylzinc to Aryl Aldehydes Catalyzed by (1S,3S)-N,NI-bis-1,3-Diphenyl-1,3-Propanediamine and its Dilithium Salts: a Mechanistic Rationale Investigation.

N,NI-bis benzyl substituted 1,3-diamine 1a, synthesized in high optical purity, and the corresponding dilithium salt 1b are used, for the first time, as chiral catalysts in the addition of ZnEt2 to aromatic aldehydes.Both 1a and 1b are able to promete the reaction but the products obtained exhibited low enantiomeric excesses.By 1H NMR and UV-CD investigation, experimental evidences about the structure of some reaction intermediates have been gained: reaction pathway consistent with spectroscopic data, chemical and stereochemical results could be postulated.

A diastereoselective synthesis of (dl)-1,3-diphenyl-1,3-propanediamines

A large-scale and practical synthesis of (dl)-1,3-diphenyl-1,3-propanediamine (1) has been achieved by a highly diastereoselective phenylcerium dichloride addition to 1-tert-butoxycarbonyl-4,5-dihydro-5-phenylpyrazole (3). Alkylcerium addition reaction to the corresponding 5-alkyl substituted 1-Boc-4,5-dihydropyrazoles was less satisfactory mainly giving ring-cleaved products. Further elaboration of the diamine 1 to the N-substituted derivatives 8a-f bearing N-methyl, N-ethyl, N-isopropyl, N-neopentyl, N-benzyl, and N-mesitylmethyl groups is described.

Reactivity and Diastereoselectivity of Grignard Reagents towards the Hydrazone Functionality in Toluene Solvent

Grignard reagents, in toluene solvent, display a strongly increased reactivity toward the hydrazone functionality.With the chiral synthon 1, a highly diastereoselective addition occurs, through chelation control, whereas with pyrazolines 4 and 9 only the d,l diastereomer is formed, leading to a very short synthesis of 1,3-diphenyl-1,3-diaminopropane (11).