59158-97-3Relevant academic research and scientific papers
Palladium-catalyzed difunctionalization/dearomatization ofN-benzylacrylamides with α-carbonyl alkyl bromides: facile access to azaspirocyclohexadienones
Peng, Chuan-Chong,Pi, Shao-Feng,Wu, Li-Jun
, p. 7602 - 7606 (2021)
An efficient palladium-catalyzed difunctionalization/dearomatization ofN-benzylacrylamides with α-carbonyl alkyl bromides as alkyl radical precursors has been described. Various α-carbonyl alkyl bromides, including α-bromoalkyl esters and ketones, reacted
Photoinduced α-Alkenylation of Katritzky Salts: Synthesis of β,?-Unsaturated Esters
Zhang, Chao-Shen,Bao, Lei,Chen, Kun-Quan,Wang, Zhi-Xiang,Chen, Xiang-Yu
supporting information, p. 1577 - 1581 (2021/03/08)
?,?-Unsaturated esters are building blocks in biologically important compounds, pharmaceuticals, and natural products. Because the current synthetic methods often require transition-metal catalysts or lack general variants, we herein describe a simple NaI-involved photoinduced deaminative alkenylation for their synthesis in the absence of photocatalysts and additives. The density functional theory study unveils that the electrostatic interaction of NaI with Katritzky salts is the key to forming the photoactive electron donor-acceptor complex, thus leading to the alkyl radicals for the alkenylation.
Preparation method of beta, gamma-unsaturated ester compound
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Paragraph 0019-0020; 0022; 0024; 0026; 0028; 0030; 0032, (2017/07/21)
The invention discloses a preparation method of beta, gamma-unsaturated ester. A structural formula of the beta, gamma-unsaturated ester is shown in the description. The preparation method of the beta, gamma-unsaturated ester comprises the following steps: adding 1,1-diphenylethlene and 2-bromopropionate into a reaction system containing a silver catalyst, an oxidant, alkali and a solvent for reacting.
Palladium-catalyzed oxidative difunctionalization of alkenes with α-carbonyl alkyl bromides initiated through a heck-type insertion: A route to indolin-2-ones
Fan, Jian-Hong,Wei, Wen-Ting,Zhou, Ming-Bo,Song, Ren-Jie,Li, Jin-Heng
, p. 6650 - 6654 (2014/07/08)
The oxidative interception of various σ-alkyl palladium(II) intermediates with additional reagents for the difunctionalization of alkenes is an important research area. A new palladium-catalyzed oxidative difunctionalization reaction of alkenes with α-carbonyl alkyl bromides is described, in which the σ-alkyl palladium(II) intermediate is generated through a Heck insertion and trapped using an aryl C(sp2)-H bond. This method can be applied to various α-carbonyl alkyl bromides, including primary, secondary, and tertiary α-bromoalkyl esters, ketones, and amides. Indolinone synthesis: A new palladium-catalyzed oxidative difunctionalization reaction of N-arylalkenes with primary, secondary, and tertiary α-carbonyl alkyl bromides proceeds through a radical process and provides indolin-2-ones in moderate to excellent yields. The reaction is initiated by a Heck insertion followed by interception of the σ-alkyl palladium(II) intermediate with aryl C(sp2)-H bonds. dppe=1,2-bis(diphenylphosphino)ethane.
A Study of the Competition between the Di-?-methane and the Azadi-?-methane Processes in 2-Vinyl-β,γ-unsaturated Oxime Derivatives. The Novel Azadi-?-methane Reactivity of β,γ-Unsaturated Oximes
Armesto, Diego,Ortiz, Maria J.,Ramos, Ana,Horspool, William M.,Mayoral, Elena P.
, p. 8115 - 8124 (2007/10/02)
A study aimed at detecting intramolecular competition between the di-?-methane (DPM) rearrangement and the azadi-?-methane (ADPM) process has been carried out.The results show that direct or acetophenone-sensitized irradiation of 2-(2,2-diphenylvinyl)-2-m
The Aza-di-?-Methane Rearrangement of β,γ-Unsaturated Oximes.
Armesto, Diego,Ramos, Ana,Mayoral, Elena P.
, p. 3785 - 3788 (2007/10/02)
Although previous studies have shown that cyclic β,γ-unsaturated oximes and oxime ethers do not undergo the aza-di-?-methane (ADPM) rearrangement, the 2-methyl-4,4-diphenyl-2-vinylbut-3-enal oxime 5a, its methyl ether 5b and the 2,2,4,4-tetraphenylbut-3-e
