59170-14-8Relevant academic research and scientific papers
Tobacco Chemistry 81. Biotransformations of (Z)-Abienol using Plant Cell Cultures of Nicotiana silvestris
Enzell, Curt R.,Nasiri, Ahmad,Forsblom, Ingrid,Johansson, Eva,Lundberg, Charlotta,et al.
, p. 375 - 379 (2007/10/02)
The transformations of (Z)-abienol (1) effected by cell cultures and cell-free extracts of Nicotiana silvestris and by horseradish peroxidase have been examined.Although this compound retarded the growth of the cell cultures in low doses and exhibited a toxic effect in high doses, a fairly rapid conversion was observed when low to moderate doses of cells cultivated under light were used.Of the many transformation products encountered twelve were identified.The major ones of these were (12R,13S)- and (12R,13R)-8,12-epoxy-14-labden-13-ols (2,5), (11E)-14,15-bisnor-8-hydroxy-11-labden-13-one (11), 12-norambreinolide (10), 12,15-epoxy-12,14-labdadien-8-ol (12) and 8-drimanol (13), and the minor (12R,13R)-, (12S,13R)-, (12S,13S)- and (12R,13S)-8,13-epoxy-14-labden-12-ols (6-9) and (12S,13S)- and (12S,13R)-8,12-epoxy-14-labden-13-ols (3,4).Horseradish peroxidase also transformed (Z)-abienol into these products.
