591738-07-7Relevant academic research and scientific papers
Design and synthesis of spiro-cyclopentenyl and spiro-[1,3]-dithiolanyl substituted pyrrolidine-5,5-trans-lactams as inhibitors of hepatitis C virus NS3/4A protease
Andrews, David M.,Jones, Paul S.,Mills, Gail,Hind, S. Lucy,Slater, Martin J.,Trivedi, Naimisha,Wareing, Katrina J.
, p. 1657 - 1660 (2007/10/03)
Using the pyrrolidine-5,5-trans-lactam template, we have designed small, neutral, mechanism-based inhibitors of hepatitis C NS3/4A protease. Compound 2b, with a spiro-cyclobutyl P1 substituent and an isopropyl carbonyl substituent at the lactam nitrogen, has an IC50 value in the replicon cell-based assay of 3 μM.
