Cas 591773-10-3,cyclo(-L-Am<sub>6</sub>-D-Tyr(Me)-L-Ile-D-Pro-)

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Check Digit Verification of cas no

The CAS Registry Mumber 591773-10-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,9,1,7,7 and 3 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 591773-10:
(8*5)+(7*9)+(6*1)+(5*7)+(4*7)+(3*3)+(2*1)+(1*0)=183
183 % 10 = 3
So 591773-10-3 is a valid CAS Registry Number.

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591773-10-3Relevant academic research and scientific papers

Novel histone deacetylase inhibitors: Cyclic tetrapeptide with trifluoromethyl and pentafluoroethyl ketones

Jose, Binoy,Oniki, Yusuke,Kato, Tamaki,Nishino, Norikazu,Sumida, Yuko,Yoshida, Minoru

, p. 5343 - 5346 (2004)

Cyclic tetrapeptides containing trifluoromethyl and pentafluoroethyl ketone as zinc binding functional group were synthesized as potent HDAC inhibitors. Evaluation by human HDAC inhibition assay and p21 promoter assay showed that these inhibitors are promising anticancer agents.

Histone deacetylase inhibitors and process for producing the same

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Page/Page column 14, (2008/06/13)

Compounds represented by formula (1) have strong inhibitory activity that is selective towards HDAC1 and HDAC4. Therefore, the compounds of the present invention are useful as pharmaceutical agents for treating or preventing diseases caused by HDAC1 and HDAC4.

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