5918-97-8

Usage

Class

Benzimidazole derivatives

Structure

Heterocyclic compound with a benzimidazole ring

Substituent

Chlorine atom at the 4-position

Pharmacological Properties

Potential pharmacological effects

Interest in Medicinal Chemistry

Valuable in medicinal chemistry research

Suitability for Drug Discovery

Structure and properties conducive to drug development

Biological Activities

Potential biological effects

Potential Starting Point

Could initiate the synthesis of novel compounds

Pharmaceutical Applications

Potential applications in drug development

Upstream product

• 769-11-9 2-chloro-6-nitroaniline 
• 59483-54-4 3-chloro-2-nitro-aniline 
• 21745-41-5 2,3-diaminochlorobenzene 
• 530-62-1 1,1'-carbonyldiimidazole 
• 2148-56-3 2-chloro-6-aminobenzoic acid 

Downstream Products

• 15965-56-7 2,7-dichloro-1H-benzo[d]imidazole 
• 15965-56-7 2,4-Dichlor-benzimidazol 

Relevant academic research and scientific papers

A Novel Method for the Synthesis of 2(3H)-Benzimidazolones, 2(3H)-Benzoxazolone, and 2(3H)-Benzothiazolone via in Situ Generated Ortho Substituted Benzoic Acid Azides: Application of Ammonium Azide and Vilsmeier Complex for Acid Azide Generation

An easy and generalized route to 2(3H)-benzimidazolones, 2(3H)-benzoxazolone and 2(3H)-benzothiazolone is attempted. A novel one-pot method for the in situ generation and cyclisation of ortho substituted benzoic acid azides is reported via the application of ammonium azide and Vilsmeier complex.

INHIBITORS OF HIV-1 NEF FOR THE TREATMENT OF HIV DISEASE

A compound of formula I, or a stereoisomer, tautomer, or pharmaceutically acceptable salt thereof: Formula I wherein X1 is benzimidazolyl, substituted benzimidazolyl, azabenzimidazolyl, substituted azabenzimidazolyl, pyrazolyl, or substituted pyrazolyl; X2 is aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, cycloalkyl, substituted cycloalkyl, (cycloalkyl)alkyl, substituted (cycloalkyl)alkyl, heterocycloalkyl, substituted heterocycloalkyl, (heterocycloalkyl)alkyl, substituted (heterocycloalkyl)alkyl, alkyl, substituted alkyl, alkoxycarbonyl, substituted alkoxycarbonyl, dialkylaminocarbonyl, substituted dialkylaminocarbonyl, (heterocycloalkyl)carbonyl, or substituted (heterocycloalkyl)carbonyl; X3 is alkyl, substituted alkyl, alkenyl, substituted alkenyl, heterocycloalkyl, substituted heterocycloalkyl, (heterocycloalkyl)alkyl, substituted (heterocycloalkyl)alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, cycloalkyl, substituted cycloalkyl, (cycloalkyl)alkyl, or substituted (cycloalkyl)alkyl; and X4 is hydroxy, amino, alkyl, or hydrogen.

Selenium-Catalyzed Carbonylative Synthesis of 2-Benzimidazolones from 2-Nitroanilines with TFBen as the CO Source

A selenium-catalyzed carbonylative reaction for the synthesis of 2-benzimidazolones from 2-nitroanilines has been developed. In this strategy, to avoid the usage of toxic CO gas, TFBen (benzene-1,3,5-triyl triformate) was used as a solid and stable CO precursor, and a variety of desired 2-benzimidazolones were produced in moderate to excellent yields.

BENZOIMIDAZOLES AS PROLYL HYDROXYLASE INHIBITORS

The present invention is directed to benzoimidazole compounds of the formula (1) and enantiomers, diastereomers, racemates, and pharmaceutically acceptable salts thereof. Compounds of the present invention are useful in pharmaceutical compositions and met