59188-28-2

Basic information

• Product Name: N-BENZOYL-PRO-PHE-ARG P-NITROANILIDE HYDROCHLORIDE
• Synonyms: BENZOYL-PROLYL-PHENYL-ALANYL-ARGININE-4-NITRANILIDE ACETATE;CHROMOZYM PK;BZ-PRO-PHE-ARG-PNA HCL;N-BENZOYL-PRO-PHE-ARG P-NITROANILIDE HYDROCHLORIDE;N-benzoyl-pro-phe-arg P-nitroanilide*hydrochlorid;Bz-Pro-Phe-Arg-Pna hydrochloride;chromokallincreine;N-Benzoyl-Pro-Phe-Arg-p-nitroanilide
• CAS NO: 59188-28-2
• Molecular Formula: C33H39ClN8O6
• Molecular Weight: 679.17
• EINECS: 232-574-5
• Product Categories: AgkistrodonEnzyme Substrates;Enzyme Substrates;Kallikrein;KallikreinEnzyme Substrates;Protease Substrates;Substrates by Enzyme
• Mol File: 59188-28-2.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: −20°C
• CAS DataBase Reference: N-BENZOYL-PRO-PHE-ARG P-NITROANILIDE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-BENZOYL-PRO-PHE-ARG P-NITROANILIDE HYDROCHLORIDE(59188-28-2)
• EPA Substance Registry System: N-BENZOYL-PRO-PHE-ARG P-NITROANILIDE HYDROCHLORIDE(59188-28-2)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 59188-28-2(Hazardous Substances Data)

Usage

Description

N-BENZOYL-PRO-PHE-ARG P-NITROANILIDE HYDROCHLORIDE is a synthetic compound that serves as a substrate for the determination of serine proteases, particularly plasma kallikrein in citrated plasma. It is a non-radioactive amidolytic chromogenic substrate, which makes it a valuable tool in the field of biochemistry and medical research.

Uses

Used in Biochemical Research:
N-BENZOYL-PRO-PHE-ARG P-NITROANILIDE HYDROCHLORIDE is used as a substrate for the determination of serine proteases, specifically plasma kallikrein in citrated plasma. This application is crucial for the study of enzyme kinetics and the analysis of plasma kallikrein activity, which plays a significant role in various physiological processes and disease mechanisms.
Used in Medical Diagnostics:
In the medical diagnostics industry, N-BENZOYL-PRO-PHE-ARG P-NITROANILIDE HYDROCHLORIDE is used as a diagnostic tool for the assessment of serine protease activity. By measuring the activity of plasma kallikrein, this compound can help in the diagnosis and monitoring of conditions related to the immune system, blood clotting, and inflammation.
Used in Drug Development:
N-BENZOYL-PRO-PHE-ARG P-NITROANILIDE HYDROCHLORIDE can also be employed in the development of new drugs targeting serine proteases, such as plasma kallikrein. By using this compound as a substrate, researchers can screen and test potential drug candidates for their ability to inhibit or modulate the activity of these enzymes, which may lead to the development of novel therapeutics for various diseases.
Used in Quality Control:
In the pharmaceutical industry, N-BENZOYL-PRO-PHE-ARG P-NITROANILIDE HYDROCHLORIDE can be utilized as a quality control standard for the assessment of serine protease activity in drug products. This ensures that the drugs maintain their intended efficacy and safety profiles throughout their shelf life and manufacturing processes.