592-79-0Relevant academic research and scientific papers
Preparation method of fluorine-containing primary amine intermediate
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Paragraph 0030; 0032; 0041; 0045, (2021/07/01)
The invention discloses a preparation method of a fluorine-containing primary amine intermediate. The method comprises the following steps: directly fluorinating an N-hydroxyalkyl phthalimide compound serving as a raw material under the action of an organic solvent and a Lewis acid catalyst to obtain an N-fluoroalkyl phthalimide intermediate, and reducing the intermediate to obtain the fluorine-containing primary amine. According to the method, the raw materials are cheap and easy to obtain, the process route is simple and easy to control, the N-hydroxyalkylphthalimide can be effectively promoted to generate the corresponding fluoride at a high conversion rate, meanwhile, the dehydrofluorination reaction in the fluorination process can be avoided, the yield of the fluoride intermediate is 85% or above, the purity reaches 97% or above, and the method is suitable for large-scale production.
