59207-15-7

Upstream product

• 33069-21-5 6β-phenoxyacetamidopenicillanic acid 1β-sulfoxide 
• 24652-74-2 methyl 6-phenoxyacetamidopenicillanate-1β-oxide 
• 131830-23-4 6β-phenoxythioacetamidopenicillanic acid 1β-sulfoxide 
• 131830-22-3 methyl 6β-phenoxythioacetamidopenicillanate 1β-sulfoxide 

Downstream Products

• 59203-76-8 (R)-3-methyl-2-((1R)-7-oxo-3-phenoxymethyl-(1rH,5cH)-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-but-3-enoic acid methyl ester 
• 40579-22-4 (2S,3S)-3-Iodo-3-methyl-8-oxo-7-(2-phenoxy-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

THE CHEMISTRY OF THE 6β-THIOAMIDOPENAM 1β-SULFOXIDES. THE 1,2,4-DITHIAZINEAZETIDINONES AND THIAZOLINEAZETIDINONES

6β-Thioamidopenam 1β-sulfoxides on thermolysis gave methyl 2-(3-substituted 4,5-dithia-2,7-diazabicyclooct-2-en-8-one-7-yl)-3-methyl-but-3-enoate (1,2,4-dithiazineazetidinones).The reaction of these compounds with halogenating agents is discussed.

Thiazoleneazetidinones from dithiazeneazetidinones

An improved process for preparing 4-thia-2,6-diazabicyclo[3,2,0]hept-2-ene-7-ones such as methyl 3-phenoxy-4-thia-2,6-diazabicyclo[3,2,0]hept-2-ene-7-one-6-isopropenylacetate which comprises extruding sulfur from dithiazeneazetidinones such as methyl 3-phenoxymethyl-4,5-dithia-2,7-diazabicyclo[4,2,0]-oct-2-ene-8-one-7-isopropenylacetate. The compounds obtained are useful intermediates in the preparation of certain 3-cephems.