59208-57-0

Upstream product

• 5720-05-8 4-methylphenylboronic acid 
• 153446-72-1 3-iodo-7-methoxy-2-phenyl-4H-chromen-4-one 
• 613-45-6 2,4-Dimethoxybenzaldehyde 
• 4440-01-1 lithium phenylacetylide 
• 878199-35-0 1-(2,4-dimethoxyphenyl)-3-phenylprop-2-yn-1-one 

Downstream Products

• 59208-58-1 7-methoxy-8-chloromethyl-3-(p.tolyl)-flavone 

Relevant academic research and scientific papers

Diversity-oriented synthesis of 3-iodochromones and heteroatom analogues via ICl-induced cyclization

The ICl-induced cyclization of heteroatom-substituted alkynones provides a simple, highly efficient approach to various 3-iodochromones and analogues. This process is run under mild conditions, tolerates various functional groups, and generally provides chromones in good to excellent yields. Subsequent palladium-catalyzed transformations afford a rapid increase in molecular complexity and a convenient preparation of a wide range of functionally substituted chromones, furans, and polycyclic compounds. Iodothiochromenones and iodoquinolinones are also prepared by similar ICl-induced cyclizations.

Flavone derivatives

New flavone derivatives to be used as analeptics having the formula STR1 wherein R1 and R2 are both methyl or ethyl, or taken together with the nitrogen atom to which they are attached represent a mononuclear 5- or -6 membered heterocyclic ring which may contain an oxygen atom as further hetero atom; R3 and R4 are hydrogen or methyl, provided that at least one of them is hydrogen, and process for the preparation thereof starting from resorcinol and phenylacetonitrile or a phenylacetonitrile derivative.