59209-71-1Relevant academic research and scientific papers
Regioselective semihydrogenation of dienes
Graham, Thomas J. A.,Poole, Thomas H.,Reese, Charles N.,Goess, Brian C.
, p. 4132 - 4138 (2011/07/07)
A one-pot, three-step strategy for the regioselective semihydrogenation of dienes is described. This procedure uses 9-BBN-H as a temporary protective group for alkenes. Yields range from 55% to 95%, and the reaction is tolerant of a variety of common functional groups. Additionally, the final elimination step of the sequence can be replaced with a peroxide-mediated alkylborane oxidation, generating regioselectively semihydrogenated product alcohols.
Discovery of a highly orally bioavailable c-5-[6-(4-Methanesulfonyloxyphenyl)hexyl]-2-methyl-1,3-dioxane-r-2-carbo xylic acid as a potent hypoglycemic and hypolipidemic agent
Pingali, Harikishore,Jain, Mukul,Shah, Shailesh,Basu, Sujay,Makadia, Pankaj,Goswami, Amitgiri,Zaware, Pandurang,Patil, Pravin,Godha, Atul,Giri, Suresh,Goel, Ashish,Patel, Megha,Patel, Harilal,Patel, Pankaj
scheme or table, p. 5586 - 5590 (2009/06/18)
A series of novel 1,3-dioxane-2-carboxylic acid derivatives containing alkyl chain tether and substituted phenyl group as a lipophilic tail have been prepared as agonists of PPARα and γ. c-5-[6-(4-Methanesulfonyloxyphenyl)hexyl]-2-methyl-1,3-dioxane-r-2-carbo xylic acid 13c exhibited potent hypoglycemic and lipid lowering activity with high oral bioavailability in animal models.
