59214-26-5Relevant articles and documents
Bis(piperazinyl or homopiperazinyl)alkanes
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, (2008/06/13)
Compounds of the formula STR1 wherein R1, R2, R3, R4, R5, and R6 are independently hydrogen, alkyl of 1 to 4 carbon atoms, hydroxyl, alkoxy of 1 to 4 carbon atoms, alkanoyloxy of 1 to 4 carbon atoms, halogen, trihalomethyl, di(lower alkyl of 1 to 4 carbon atoms)amino, (alkoxy of 1 to 4 carbon atoms)carbonyl, nitro, cyano or alkanoyl of 1 to 3 carbon atoms; R7 and R8 are independently hydrogen, methyl, hydroxyl, carboxyl, (alkoxy of 1 to 4 carbon atoms)carbonyl, hydroxymethyl, phenyl, or p-chlorophenyl; R9 and R10 are independently hydrogen or methyl; j and k are independently 0, 1, 2, or 3, their sum being no more than 4; m and n are independently 0, 1, 2, or 3, their sum being no more than 4; A is --CH2 -- or --CH2 --CH2 --; R7 and R9 together are oxo, provided k is other than o; R8 and R10 together are oxo, provided m is other than o; R11 and R12 independently represent hydrogen or one to four methyl substituents on the carbon atoms of the piperazine ring (A=--CH2 --); R13, R14, R15, and R16 are independently hydrogen or methyl; R13 and R14 together are oxo; R15 and R16 together are oxo; and X is alkylene of 1 to 2 carbon atoms, optionally hydroxy-substituted; or a non-toxic, pharmacologically acceptable acid addition salt thereof, are useful as antiallergic and anti-inflammatory agents.