59215-40-6

Usage

Uses

Used in Pharmaceutical Industry:
PYRIMIDINE, 5-CHLORO-2-(1-PIPERAZINYL)is used as a building block for the development of potential antiviral, antifungal, and anticancer agents. Its unique structure allows for the creation of various bioactive molecules with therapeutic properties.
Used in Agrochemical Industry:
PYRIMIDINE, 5-CHLORO-2-(1-PIPERAZINYL)is used as a precursor in the production of various drugs and bioactive molecules, specifically in the manufacturing of pesticides, herbicides, and other agricultural chemicals. Its versatility in chemical synthesis contributes to the development of effective and targeted agrochemicals.

Upstream product

• 99931-84-7 4-(5-chloro-pyrimidin-2-yl)-piperazine-1-carboxylic acid ethyl ester 
• 99931-83-6 ethyl 4-(2-pirymidinyl)-1-piperazinecarboxylate 

Downstream Products

• 99931-64-3 4-[4-(5-Chloro-pyrimidin-2-yl)-piperazin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one 

Relevant academic research and scientific papers

Synthesis and Biological Characterization of α-(4-Fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol and Analogues as Potential Atypical Antipsychotic Agents

A series of 1-(pyrimidin-2-yl)piperazine derivatives were prepared and evaluated in receptor binding assays and in in vivo behavioral paradigms as potential atypical antipsychotic agents.Compound 16 (BMS 181100 (formerly BMY 14802)) emerged as the lead compound from within the series on the basis of its good activity and duration of action in the inhibition of both conditioned avoidance responding and apomorphine-induced stereotopy in the rat.Compound 16 not only failed to induce catalepsy in the rat but was quite effective in reversing the cataleptic effect of neurolepti c agents, thus indicating a low propensity for causing extrapyramidal side effects.In comparison to reference antipsychotic agents, 16 appeared to be less sedating and was relatively weaker in causing muscle incoordination.The compound was essentially inactive in binding to dopamine D2 receptors and its chronic administration to rats did not result in dopamine receptor supersensitivity.It exhibited modest to weak affinity for 5-HT1A and α1 receptors but was found to be a fairly potent ligand for ? binding sites (IC50 vs (+)--3-PPP = 112 nM).Although the resolved enantiomers of racemic 16 did not show dramatic differences from racemate or from each other in most tests, the R(+) enantiomer was up to 11-fold more potent than its antipode in binding to ? sites.Several studies have indicated that 16 may be a limbic-selective agent which may modulate dopaminergic activity by an indirect mechanism.The compound has been selected for clinical evaluation in the treatment of psychosis.

Antipsychotic 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine derivatives

Disubstituted N,N-piperazinyl derivatives are disclosed wherein one substituent is a pyrimidin-2-yl ring and the other is a 4 carbon chain attached to a p-fluorophenyl ring at the terminal carbon. The terminal carbon of this butylene chain is also bonded to an oxygen atom as part of a carbonyl, carbinol, or ketal functionality. These compounds possess psychotropic properties, particularly atypical antipsychotic activity of good duration. By virtue of pre-clinical pharmacological testing, these compounds appear useful as potential antipsychotic agents which lack the typical movement disorder side-effects of standard antipsychotic agents.