59229-35-5Relevant academic research and scientific papers
Synthesis of amine derivatives
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, (2008/06/13)
An amine of the formula, STR1 wherein R1, R2, R3, R4 and R5 are each hydrogen, alkyl or the like and n is 1, 2 or 3, including α-phenyl-β-(p-tolyl)-ethylamine, which is useful as an optically resolving agent, an intermediate of medicines and the like, is effectively produced by a novel process comprising hydrolysis of the corresponding nitrile of the formula, STR2 wherein R1, R2, R3, R4, R5 and n are the same as above, followed by alkali-decomposition of the resulting amide of the formula, STR3 wherein R1, R2, R3, R4, R5 and n are the same as above. An amide including the above one is effectively produced by hydrolysis of the corresponding nitrile in the presence of a base and hydrogen peroxide using an organic quaternary ammonium salt and/or a tertiary amine as a catalyst.
