59236-40-7Relevant academic research and scientific papers
New NO-donors with antithrombotic and vasodilating activities, IX. Thiadiazole nitrosimines
Rehse,Ludtke
, p. 17 - 20 (1995)
Twenty 1,3,4-thiadiazole-2-nitrosimines and two 1,2,4-thiadiazole-5-nitrosimines were synthesized and assayed in the Born-test for their antiplatelet activity. Only two 1,3,4-thiadiazoles inhibited the aggregation at IC50 10 μmol/L. In an in vivo thrombosis model only in arterioles a small inhibition of thrombus formation was observed. The poor test results correspond to a very high chemical stability of the titel nitrosimines.
