59256-26-7Relevant academic research and scientific papers
Sulfonamide Inhibitors of β-Catenin Signaling as Anticancer Agents with Different Output on c-MYC
Di Magno, Laura,Di Pastena, Fiorella,Puxeddu, Michela,La Regina, Giuseppe,Coluccia, Antonio,Ciogli, Alessia,Manetto, Simone,Maroder, Marella,Canettieri, Gianluca,Silvestri, Romano,Nalli, Marianna
supporting information, p. 2264 - 2268 (2020/10/19)
The Wnt/β-catenin pathway is often found deregulated in cancer. The aberrant accumulation of β-catenin in the cell nucleus results in the development of various malignancies. Specific drugs against this signaling pathway for clinical treatments have not b
Design, synthesis and biological evaluation of novel non-peptide boronic acid derivatives as proteasome inhibitors
Zhang, Jiankang,Shen, Luqing,Wang, Jincheng,Luo, Peihua,Hu, Yongzhou
, p. 38 - 45 (2014/01/17)
A series of novel non-peptide boronic acid derivatives were designed and synthesized via rational drug design principles. All target compounds were screened for the proteasome inhibitory activities in vitro. Selected compounds (6a and 7j) were evaluated f
