59261-43-7 Usage
Uses
Used in Pharmaceutical Research:
1-(1,3-dioxolan-2-yl)-4-methylisoquinolin-5-amine is used as a research compound for exploring its potential biological activities and interactions with various biological targets. Its unique structure may provide insights into the development of new drugs and therapies.
Used in Drug Development:
In the drug development industry, 1-(1,3-dioxolan-2-yl)-4-methylisoquinolin-5-amine is used as a lead compound for the design and synthesis of novel pharmaceuticals. Its structural features may be exploited to create new molecules with improved pharmacological properties and therapeutic potential.
Used in Chemical Synthesis:
1-(1,3-dioxolan-2-yl)-4-methylisoquinolin-5-amine may also be utilized as an intermediate or building block in the synthesis of more complex organic molecules, particularly in the fields of medicinal chemistry and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 59261-43-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,9,2,6 and 1 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 59261-43:
(7*5)+(6*9)+(5*2)+(4*6)+(3*1)+(2*4)+(1*3)=137
137 % 10 = 7
So 59261-43-7 is a valid CAS Registry Number.
59261-43-7Relevant academic research and scientific papers
Potential antitumor agents. 13. 4 Methyl 5 amino 1 formylisoquinoline thiosemicarbazone
Agrawal,Mooney,Sartorelli
, p. 970 - 972 (2007/10/04)
4 Methyl 5 amino 1 formylisoquinoline thiosemicarbazone has been synthesized in an attempt to obtain (a) high affinity for the target enzyme ribonucleotide reductase, (b) water solubility as an acid salt of the amine, (c) steric protection of the amino group from in vivo acetylation, and (d) insensitivity to O glucuronidation, a major factor in inactivity in man of 5 hydroxy 2 formylpyridine thiosemicarbazone. The synthesis was achieved by nitration of 1,4 dimethylisoquinoline at the 5 position followed by selective oxidation with selenium dioxide to the corresponding 1 carboxaldehyde. The aldehyde group was protected by conversion to the cyclic ethylene acetal which was then catalytically reduced to produce the 5 amino derivative. Reaction with thiosemicarbazide in the presence of hydrochloric acid yielded the desired derivative. This agent was found to be an effective antineoplastic agent in mice bearing Sarcoma 180 ascites cells and at the maximum effective daily dose of 10 mg/kg increased the average survival of animals threefold over untreated tumor bearing controls.
