59278-68-1

Basic information

• Product Name: 5-BroMo-4-phenylthiazole
• Synonyms: 5-BroMo-4-phenylthiazole
• CAS NO: 59278-68-1
• Molecular Formula: C₉H₆BrNS
• Molecular Weight: 240.11964
• Mol File: 59278-68-1.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 5-BroMo-4-phenylthiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BroMo-4-phenylthiazole(59278-68-1)
• EPA Substance Registry System: 5-BroMo-4-phenylthiazole(59278-68-1)

Safety Data

• Hazardous Substances Data: 59278-68-1(Hazardous Substances Data)

Upstream product

• 188585-15-1 2,5-dibromo-4-phenylthiazole 

Relevant articles and documents

NaBH4-TMEDA and a palladium catalyst as efficient regio- and chemoselective system for the hydrodehalogenation of halogenated heterocycles

The pair NaBH4-TMEDA as hydride source and a palladium catalyst in THF prove to be an efficient system for the hydrodehalogenation of halogenated heterocycles with one or more heteroatoms. In general, Pd(OAc) 2-PPh3 rapidly hydrodehalogenates reactive halo-heterocycles such as bromo-pyridines, -quinolines, -thiophenes, -indoles, -imidazoles, etc., at room temperature in very good yields, whereas in most cases PdCl2(dppf) reduces less reactive halides such as chloro-pyridines, -quinolines, -pyrimidines and bromo-indoles, -benzofurans, etc. Moreover, PdCl2(tbpf) shows to be even more active removing the 2- and 5-chlorine from both thiophene and thiazole rings. The reaction conditions tolerate various functional groups, allowing highly chemoselective reactions in the presence of halide, ester, alkyne, alkene and nitrile substituents. Moreover, with a proper selection of the catalyst it is also possible to obtain a good control in the regioselective hydrodehalogenation of a variety of polyhalogenated substrates.