59280-69-2 Usage
Uses
Used in Pharmaceutical Industry:
3-Bromo-4-methylquinoline is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows it to be a valuable building block for the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Bromo-4-methylquinoline serves as an intermediate in the production of agrochemicals. Its properties make it suitable for the synthesis of compounds that can be used in pest control and crop protection.
Used in Fine Chemicals Industry:
3-Bromo-4-methylquinoline is also utilized as an intermediate in the synthesis of other fine chemicals. Its versatility in chemical reactions enables the creation of a wide range of specialty chemicals for various applications.
Used in Heterocyclic Compounds Preparation:
3-BROMO-4-METHYLQUINOLINE is used as a building block in the preparation of various heterocyclic compounds. Its structural attributes make it an essential component in the synthesis of complex organic molecules with potential applications in different fields.
It is crucial to handle 3-bromo-4-methylquinoline with care and adhere to proper safety protocols when working with it in a laboratory setting to ensure the safety of both the personnel and the environment.
Check Digit Verification of cas no
The CAS Registry Mumber 59280-69-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,9,2,8 and 0 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 59280-69:
(7*5)+(6*9)+(5*2)+(4*8)+(3*0)+(2*6)+(1*9)=152
152 % 10 = 2
So 59280-69-2 is a valid CAS Registry Number.
InChI:InChI=1/C10H8BrN/c1-7-8-4-2-3-5-10(8)12-6-9(7)11/h2-6H,1H3
59280-69-2Relevant academic research and scientific papers
Catalytic atroposelective dynamic kinetic resolutions and kinetic resolutions towards 3-arylquinolinesviaSNAr
Cardenas, Mariel M.,Saputra, Mirza A.,Gordon, Deane A.,Sanchez, Andrea N.,Yamamoto, Nobuyuki,Gustafson, Jeffrey L.
supporting information, p. 10087 - 10090 (2021/10/06)
Herein we report the catalytic atroposelective syntheses of pharmaceutically relevant 3-arylquinolinesviathe nucleophilic aromatic substitution (SNAr) of thiophenols into 3-aryl-2-fluoroquinolines mediated by catalytic amounts of Cinchona alkaloid-derived ureas. These reactions displayed a spectrum of dynamic kinetic resolution (DKR) and kinetic resolution (KR) characters depending upon the stereochemical stability of the starting material. Low barrier substrates proceededviaDKR while higher barrier substrates proceededviaKR. On the other hand, substrates with intermediate stabilities displayed hallmarks of both DKR and KR. Finally, we also show that we can functionalize the atropisomerically enriched quinolines into pharmaceutically privileged scaffolds with minimal observed racemization.
