59288-01-6Relevant academic research and scientific papers
Efficient synthesis of 5-nitro-benzo[b]furans via 2-bromo-4-nitro-phenyl acetates
Bochicchio, Antonella,Chiummiento, Lucia,Funicello, Maria,Lopardo, Maria Teresa,Lupattelli, Paolo
experimental part, p. 2824 - 2827 (2010/07/04)
Acetylation/Sonogashira cross-coupling reaction/cyclization has been carried out in one-pot using a Na2PdCl4/2-(di-tert-butylphosphino)-N-phenylindole/CuI system in TMEDA to give 5-nitro-2-substituted benzo[b]furans in excellent yields. We also describe the extension of this method to 4-EWG-2-bromo-phenols obtaining 2,5-disubstituted-benzo[b]furans in good yields.
