59288-43-6 Usage
Uses
Used in Pharmaceutical Industry:
5-Hydroxy-6-nitropyridine-3-carboxylic acid is used as a key intermediate in the synthesis of aminoheteroaryl protein kinase inhibitors. These inhibitors play a crucial role in the development of targeted therapies for various diseases, including cancer and other proliferative disorders. 5-Hydroxy-6-nitropyridine-3-carboxylic acid's unique structure allows it to interact with specific protein kinases, thereby modulating their activity and potentially leading to therapeutic benefits.
Used in Cancer Treatment:
In the field of oncology, 5-Hydroxy-6-nitropyridine-3-carboxylic acid is utilized as a building block for the development of novel protein kinase inhibitors that target cancer cells. These inhibitors can disrupt the signaling pathways involved in cell proliferation and survival, thereby inhibiting tumor growth and progression. 5-Hydroxy-6-nitropyridine-3-carboxylic acid's potential to be incorporated into various drug candidates makes it a valuable asset in the fight against cancer.
Used in Drug Design and Development:
5-Hydroxy-6-nitropyridine-3-carboxylic acid is also employed in the design and development of new drugs with improved pharmacological properties. Its unique chemical structure can be further modified and optimized to enhance the potency, selectivity, and pharmacokinetic profile of the resulting drug candidates. This makes it a versatile tool in the hands of medicinal chemists, who can leverage its properties to create innovative therapeutic agents for a wide range of diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 59288-43-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,9,2,8 and 8 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 59288-43:
(7*5)+(6*9)+(5*2)+(4*8)+(3*8)+(2*4)+(1*3)=166
166 % 10 = 6
So 59288-43-6 is a valid CAS Registry Number.
InChI:InChI=1/C6H4N2O5/c9-4-1-3(6(10)11)2-7-5(4)8(12)13/h1-2,9H,(H,10,11)
59288-43-6Relevant academic research and scientific papers
PYRIMIDINE TBK/IKKε INHIBITOR COMPOUNDS AND USES THEREOF
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Paragraph 00274, (2019/05/10)
The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as TBK/IKKε inhibitors.
Substituted dihydropyrido[3,4-b]pyrazinones as dual inhibitors of bet proteins and polo-like kinases
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Paragraph 0241, (2016/10/10)
The present invention relates to substituted dihydropyrido[3,4-b]pyrazinones as dual inhibitors of BET proteins, especially BRD4 proteins and polo-like kinases, especially Plk-1 proteins, of the general formula (I) in which A, X, R1, R2, R3, R4, R5, R6, R
N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS
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Page/Page column 55; 56, (2014/12/12)
A compound of formula (I), or a pharmaceutically acceptable salt thereof and a pharmaceutical composition comprising the compound. The compound is an inhibitor of interactions between S100A9 and interaction partners such as RAGE, TLR4 and EMMPRIN and as such is useful in the treatment of disorders such as cancer, autoimmune disorders, inflammatory disorders and neurodegenerative disorders.
AMINOHETEROARYL COMPOUNDS AS PROTEIN TYROSINE KINASE INHIBITORS
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Page/Page column 77, (2010/10/20)
Aminoheteroaryl compounds are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.
