59290-85-6

Basic information

• Product Name: 3-NITRO-PYRIDINE-2-CARBOXYLIC ACID
• Synonyms: 3-NITRO-PYRIDINE-2-CARBOXYLIC ACID;3-Nitropyridine-2-Carboxylic;3-nitropicolinic acid;3-Nitro-pyridine-2-carboxylic acid amide;2-Carboxy-3-nitropyridine;3-nitro- (6CI);3-Nitro-2-pyridinecarboxylicacid;3-Nitro-2-pyridinecarboxy...
• CAS NO: 59290-85-6
• Molecular Formula: C₆H₄N₂O₄
• Molecular Weight: 168.11
• Mol File: 59290-85-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 105 °C
• Boiling Point: 369.5oC at 760 mmHg
• Flash Point: 177.3oC
• Appearance: /
• Density: 1.57g/cm3
• Vapor Pressure: 4.11E-06mmHg at 25°C
• Refractive Index: 1.624
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 1.27±0.30(Predicted)
• CAS DataBase Reference: 3-NITRO-PYRIDINE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-NITRO-PYRIDINE-2-CARBOXYLIC ACID(59290-85-6)
• EPA Substance Registry System: 3-NITRO-PYRIDINE-2-CARBOXYLIC ACID(59290-85-6)

Safety Data

• Hazardous Substances Data: 59290-85-6(Hazardous Substances Data)

Usage

General Description

3-NITRO-PYRIDINE-2-CARBOXYLIC ACID, also known as 3-nitropyridine-2-carboxylic acid, is a chemical compound that consists of a pyridine ring with a carboxylic acid group and a nitro group attached to the 3rd and 2nd carbon atoms, respectively. It is a yellow crystalline solid with the molecular formula C6H4N2O4 and a molecular weight of 168.106 g/mol. 3-NITRO-PYRIDINE-2-CARBOXYLIC ACID is used in the synthesis of pharmaceuticals, agrochemicals, and dyes. It is also employed as an intermediate in the production of various chemicals and is a key building block for organic synthesis. Additionally, 3-nitropyridine-2-carboxylic acid has been studied for its potential biological activities and pharmacological properties.

InChI:InChI=1/C6H4N2O4/c9-6(10)5-4(8(11)12)2-1-3-7-5/h1-3H,(H,9,10)

Upstream product

• 18699-87-1 2-methyl-3-nitropyridine 
• 10261-94-6 3-nitropyridine-2-carboxaldehyde 
• 5470-18-8 2-Chloro-3-nitropyridine 

Downstream Products

• 878399-54-3 3-nitropyridin-2-carboxylic acid-(4-fluorophenyl)-amide 
• 5470-18-8 2-Chloro-3-nitropyridine 
• 99368-19-1 3-amino-N-methylpyridine-2-carboxamide 
• 19755-53-4 2-bromo-3-nitropyridine 
• 1462-86-8 3-amino-pyridine-2-carboxylic acid 

Relevant articles and documents

INHIBITORS OF FOCAL ADHESION KINASE

The invention provides inhibitors of focal adhesion kinase, an enzyme involved in the attachment of the cytoskeleton of a cell to an extracellular matrix, which has been implicated in processes such as cell migration, cell proliferation, and cell survival. The inhibitors are derivatives of a 5-substituted 2,4-diaminopyridine wherein the substituents are as defined herein. The invention also provides a method of using the inhibitors in treatment of cancer, and methods of preparation of the inhibitors by use of coupling reactions.

Fused ring 4-oxopyrimidine derivative

The present invention provides a compound represented by formula (I) below, or a pharmaceutically acceptable salt thereof, which, having histamine H3 receptor antagonist or inverse agonist activity, is useful in the prophylaxis or therapy of metabolic diseases, circulatory diseases, or nervous system diseases. [where, for example, Ar is a divalent group formed by eliminating two hydrogen atoms from benzene, X1 is a nitrogen atom, sulfur atom or oxygen atom, R1 is a 5- to 6-membered heteroaryl group, Ring A is a 5- to 6-membered heteroaryl ring, R2 and R3 are amino groups or alkylamino groups, and X2 is represented by formula (II): (where R4 and R5 are lower alkyl groups, and n is an integer from 2 to 4).]